Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses
Ovadia C, Seed PT, Sklavounos A, Geenes V, Di Illio C, Chambers J, Kohari K, Bacq Y, Bozkurt N, Brun-Furrer R, Bull L, Estiú MC, Grymowicz M, Gunaydin B, Hague WM, Haslinger C, Hu Y, Kawakita T, Kebapcilar AG, Kebapcilar L, Kondrackienė J, Koster MPH, Kowalska-Kańka A, Kupčinskas L, Lee RH, Locatelli A, Macias RIR, Marschall HU, Oudijk MA, Raz Y, Rimon E, Shan D, Shao Y, Tribe R, Tripodi V, Abide C, Yenidede I, Thornton JG, Chappell LC, Williamson C. Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses. The Lancet 2019, 393: 899-909. PMID: 30773280, PMCID: PMC6396441, DOI: 10.1016/s0140-6736(18)31877-4.Peer-Reviewed Original ResearchMeSH KeywordsAlanine TransaminaseAspartate AminotransferasesBile Acids and SaltsBilirubinBiomarkersCase-Control StudiesCholestasis, IntrahepaticCohort StudiesFemaleHumansInfant, NewbornPerinatal DeathPregnancyPregnancy ComplicationsPremature BirthRandomized Controlled Trials as TopicRisk FactorsROC CurveStillbirthConceptsSerum bile acid concentrationsBile acid concentrationsIndividual patient dataAdverse perinatal outcomesRisk of stillbirthPerinatal outcomesTotal bile acidsIntrahepatic cholestasisSingleton pregnanciesBile acidsBiochemical markersPregnancy casesHigh riskSerum total bile acidsTotal bile acid concentrationAdverse perinatal effectsPatient dataElevated bile acid concentrationsPopulation-based studyCase-control studyPrevalence of stillbirthUK National InstituteStepwise logistic regressionSpecific biochemical markersFull-text articles