2015
FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders
Mariani J, Coppola G, Zhang P, Abyzov A, Provini L, Tomasini L, Amenduni M, Szekely A, Palejev D, Wilson M, Gerstein M, Grigorenko EL, Chawarska K, Pelphrey KA, Howe JR, Vaccarino FM. FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders. Cell 2015, 162: 375-390. PMID: 26186191, PMCID: PMC4519016, DOI: 10.1016/j.cell.2015.06.034.Peer-Reviewed Original ResearchConceptsInduced pluripotent stem cellsGene network analysisGene network modulesUpregulation of genesTranscription factor Foxg1Accelerated cell cyclePluripotent stem cellsRNA interferenceGenetic basisSynaptic assemblyCell cycleBrain developmentNeuron fateNeuron differentiationNeuronal differentiationGenomic mutationsHuman brain developmentIdiopathic autism spectrum disorderAltered expressionStem cellsCell proliferationFOXG1ASD pathophysiologyNetwork modulesNeural cultures
2011
Early Generalized Overgrowth in Boys With Autism
Chawarska K, Campbell D, Chen L, Shic F, Klin A, Chang J. Early Generalized Overgrowth in Boys With Autism. JAMA Psychiatry 2011, 68: 1021-1031. PMID: 21969460, PMCID: PMC4878118, DOI: 10.1001/archgenpsychiatry.2011.106.Peer-Reviewed Original ResearchConceptsLower adaptive functioningAdaptive functioning levelPervasive developmental disorderCognitive functioningAdaptive functioningCognitive featuresSocial deficitsHC growthAge-related changesUniversity-based clinicAutismFunctioning levelsAge 24 monthsAutistic disorderClinical groupsDevelopmental disordersDevelopmental problemsFunctioningDevelopmental delayBoysAge 2 yearsGeneralized overgrowthOvergrowth patternGreater severityFirst year