2021
Hominini-specific regulation of CBLN2 increases prefrontal spinogenesis
Shibata M, Pattabiraman K, Muchnik SK, Kaur N, Morozov YM, Cheng X, Waxman SG, Sestan N. Hominini-specific regulation of CBLN2 increases prefrontal spinogenesis. Nature 2021, 598: 489-494. PMID: 34599306, PMCID: PMC9018127, DOI: 10.1038/s41586-021-03952-y.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalcium-Binding ProteinsDendritesEnhancer Elements, GeneticFemaleHumansIntercellular Signaling Peptides and ProteinsMacacaMental DisordersMiceNerve Tissue ProteinsNervous System DiseasesNeural Cell Adhesion MoleculesPhylogenyPrefrontal CortexPromoter Regions, GeneticSOXD Transcription FactorsTranscriptomeUp-RegulationConceptsCerebellin 2Prefrontal cortexCerebral cortex regionsDendritic spine formationInitiation of synaptogenesisLaminar distributionDendritic spinesNervous systemNeuropsychiatric disordersSpine formationLevel of expressionCortex regionsGenetic humanizationCortical gradientsDisproportionate increaseSpecies differencesNeurexinsSpinogenesisDysfunctionMolecular basisPathogenesisExpressionCortexSynaptogenesisSpine
2016
Subpallial Enhancer Transgenic Lines: a Data and Tool Resource to Study Transcriptional Regulation of GABAergic Cell Fate
Silberberg SN, Taher L, Lindtner S, Sandberg M, Nord AS, Vogt D, Mckinsey GL, Hoch R, Pattabiraman K, Zhang D, Ferran JL, Rajkovic A, Golonzhka O, Kim C, Zeng H, Puelles L, Visel A, Rubenstein JLR. Subpallial Enhancer Transgenic Lines: a Data and Tool Resource to Study Transcriptional Regulation of GABAergic Cell Fate. Neuron 2016, 92: 59-74. PMID: 27710791, PMCID: PMC5063253, DOI: 10.1016/j.neuron.2016.09.027.Peer-Reviewed Original ResearchConceptsGABAergic cell fateEnhancer activityTranscriptional regulationCell fateNovel molecular mechanismStable transgenic mouse linesTranscriptional circuitryTransgenic linesTranscription factorsTranscriptional mechanismsDifferent enhancer elementsFate mapEnhancer elementsMolecular mechanismsTransgenic mouse lineForebrain developmentDistinct domainsMouse linesRegulationAmygdala neuronsBasal gangliaFateSpecific subtypesMutantsUnique tool