2016
NgBR is essential for endothelial cell glycosylation and vascular development
Park EJ, Grabińska K, Guan Z, Sessa WC. NgBR is essential for endothelial cell glycosylation and vascular development. EMBO Reports 2016, 17: 167-177. PMID: 26755743, PMCID: PMC5290814, DOI: 10.15252/embr.201540789.Peer-Reviewed Original ResearchConceptsVascular developmentCis-prenyltransferase activityEmbryonic lethalityKnockout embryosProtein glycosylationTransmembrane proteinDefective glycosylationCell glycosylationEndothelial cellsDevelopment defectsKnockout resultsNgBRDolichol phosphateVE-cadherinGlycosylationYolk sacProteinEndothelial proteinsCellsIntegrated roleEmbryogenesisSubunitsEmbryosApoptosisEnd products
2005
Functional relationships between the Saccharomyces cerevisiae cis-prenyltransferases required for dolichol biosynthesis.
Grabińska K, Sosińska G, Orłowski J, Swiezewska E, Berges T, Karst F, Palamarczyk G. Functional relationships between the Saccharomyces cerevisiae cis-prenyltransferases required for dolichol biosynthesis. Acta Biochimica Polonica 2005, 52: 221-32. PMID: 15827619, DOI: 10.18388/abp.2005_3511.Peer-Reviewed Original ResearchConceptsEnzymatic activityCis-prenyltransferase activityLong-chain dolicholsYeast SaccharomycesShorter speciesRER2Dolichol biosynthesisLevels of mRNADiphosphate formationIsoprene unitsSRT1SaccharomycesOverexpressionDolichol contentGenesPreferential synthesisProteinFunctional relationshipMRNADPM1TranscriptionBiosynthesisFarnesylSpecies