Remnant Lipoprotein Cholesterol and Mortality After Acute Myocardial Infarction: Further Evidence for a Hypercholesterolemia Paradox From the TRIUMPH Registry
Martin SS, Faridi KF, Joshi PH, Blaha MJ, Kulkarni KR, Khokhar AA, Maddox TM, Havranek EP, Toth PP, Tang F, Spertus JA, Jones SR. Remnant Lipoprotein Cholesterol and Mortality After Acute Myocardial Infarction: Further Evidence for a Hypercholesterolemia Paradox From the TRIUMPH Registry. Clinical Cardiology 2015, 38: 660-667. PMID: 26459191, PMCID: PMC4715617, DOI: 10.1002/clc.22470.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersChi-Square DistributionCholesterolFemaleHumansHypercholesterolemiaKaplan-Meier EstimateLinear ModelsLipoproteinsMaleMiddle AgedMyocardial InfarctionProportional Hazards ModelsProspective StudiesProtective FactorsRegistriesRisk AssessmentRisk FactorsTime FactorsTriglyceridesUnited StatesUp-RegulationConceptsAcute myocardial infarctionHigh RLP-C levelsRLP-C levelsRemnant lipoprotein cholesterolLipoprotein cholesterolHazard ratioMyocardial infarctionAcute Coronary Events (GRACE) scoreIntermediate-density lipoprotein cholesterolLow-density lipoprotein cholesterolLipoprotein cholesterol subfractionsMortality 2 yearsUnknown protective factorsLead-time biasRegression hazard ratiosTriglyceride-rich lipoproteinsPrior observational studiesTRIUMPH registryCholesterol subfractionsLowest tertileAMI outcomesAMI survivorsHypercholesterolemic patientsMiddle tertileGlobal RegistryRelationship of the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio to the remainder of the lipid profile: The Very Large Database of Lipids-4 (VLDL-4) study
Quispe R, Manalac RJ, Faridi KF, Blaha MJ, Toth PP, Kulkarni KR, Nasir K, Virani SS, Banach M, Blumenthal RS, Martin SS, Jones SR. Relationship of the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio to the remainder of the lipid profile: The Very Large Database of Lipids-4 (VLDL-4) study. Atherosclerosis 2015, 242: 243-250. PMID: 26232164, DOI: 10.1016/j.atherosclerosis.2015.06.057.Peer-Reviewed Original ResearchConceptsHigh-density lipoprotein cholesterol ratioLipoprotein cholesterol ratioLipid profileLDL densityCholesterol ratioAtherogenic lipid phenotypeLevels of RLPMedian TgMetabolic syndromeLipid parametersCohort representativeInsulin resistanceMean ageStudy populationElevated TGGeneral U.S.Higher RLPUS individualsLipid phenotypesDemographic informationHighest relative increaseTriglyceridesRLPAgeRelative increase