Onconase mediated NFKβ downregulation in malignant pleural mesothelioma
Goparaju CM, Blasberg JD, Volinia S, Palatini J, Ivanov S, Donington JS, Croce C, Carbone M, Yang H, Pass HI. Onconase mediated NFKβ downregulation in malignant pleural mesothelioma. Oncogene 2011, 30: 2767-2777. PMID: 21317924, PMCID: PMC3118086, DOI: 10.1038/onc.2010.643.Peer-Reviewed Original ResearchConceptsDownstream targetsMiRNA mimicsCell linesCell proliferationSoft agar colony formationMPM cell linesMiRNA expression patternsAgar colony formationProtein translationABC transportersExpression patternsGene expressionReverse transcription-PCRSpecific microRNAsBcl-xLCertain miRNAsMiRNA expressionOnconaseFunctional assaysClosure assayFunctional implicationsMatrigel invasionColony formationCell apoptosisNuclear factor kappa B