2021
A distinct association of inflammatory molecules with outcomes of COVID-19 in younger versus older adults
Shin JJ, Jeon S, Unlu S, Par-Young J, Shin MS, Kuster JK, Afinogenova Y, Kang Y, Simonov M, Buller G, Bucala R, Kang I. A distinct association of inflammatory molecules with outcomes of COVID-19 in younger versus older adults. Clinical Immunology 2021, 232: 108857. PMID: 34560283, PMCID: PMC8455237, DOI: 10.1016/j.clim.2021.108857.Peer-Reviewed Original ResearchConceptsClinical outcomesOlder adultsInflammatory moleculesHospitalized adult COVID-19 patientsOlder subjectsAdult COVID-19 patientsSoluble IL-2 receptor alphaIL-2 receptor alphaCOVID-19Different immunologic mechanismsAcute phase reactantsCOVID-19 patientsDevastating clinical outcomesT cell activationImmunologic mechanismsIL-10Immune agingInflammatory processImmune mechanismsPhase reactantsSevere diseaseReceptor alphaCell activationDisease severityBiological predictors
2020
Diagnosis of SARS-CoV-2 infection in the setting of the cytokine release syndrome
Azar MM, Shin JJ, Kang I, Landry M. Diagnosis of SARS-CoV-2 infection in the setting of the cytokine release syndrome. Expert Review Of Molecular Diagnostics 2020, 20: 1087-1097. PMID: 32990479, DOI: 10.1080/14737159.2020.1830760.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Immune profileCOVID-19SARS-CoV-2 infectionCytokine release syndromeAdaptive immune cellsMultiple inflammatory cytokinesSARS-CoV-2 RNAFalse-negative resultsRelease syndromeInfectious complicationsIL-10Laboratory markersD-dimerInflammatory moleculesIP-10IL-6Inflammatory cytokinesMCP-1Acute diagnosisIL-2Immune cellsClinical severityTherapeutic benefitPathogenic contribution