2011
The Multifunctional LigB Adhesin Binds Homeostatic Proteins with Potential Roles in Cutaneous Infection by Pathogenic Leptospira interrogans
Choy HA, Kelley MM, Croda J, Matsunaga J, Babbitt JT, Ko AI, Picardeau M, Haake DA. The Multifunctional LigB Adhesin Binds Homeostatic Proteins with Potential Roles in Cutaneous Infection by Pathogenic Leptospira interrogans. PLOS ONE 2011, 6: e16879. PMID: 21347378, PMCID: PMC3036719, DOI: 10.1371/journal.pone.0016879.Peer-Reviewed Original Research
2007
Leptospira Immunoglobulin-Like Proteins as a Serodiagnostic Marker for Acute Leptospirosis
Croda J, Ramos JG, Matsunaga J, Queiroz A, Homma A, Riley LW, Haake DA, Reis MG, Ko AI. Leptospira Immunoglobulin-Like Proteins as a Serodiagnostic Marker for Acute Leptospirosis. Journal Of Clinical Microbiology 2007, 45: 1528-1534. PMID: 17360842, PMCID: PMC1865864, DOI: 10.1128/jcm.02344-06.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, BacterialBacterial ProteinsBiomarkersBrazilCase-Control StudiesHumansImmunoglobulin GImmunoglobulin MImmunoglobulinsLeptospiraLeptospirosisConceptsSerodiagnostic markerDays of illnessLarge disease burdenLeptospira immunoglobulin-like proteinAcute infectionClinical presentationAcute leptospirosisIgM antibodiesAntibody responseDisease burdenPutative virulence determinantsIgM enzymeTimely diagnosisSevere formHealthy individualsMicroagglutination testPatientsUrban outbreaksHigh mortalityInfectious diseasesPathogenic serovarsLeptospirosisImmunosorbent assaySerumSpecific markers
2003
Pathogenic Leptospira species express surface‐exposed proteins belonging to the bacterial immunoglobulin superfamily
Matsunaga J, Barocchi MA, Croda J, Young TA, Sanchez Y, Siqueira I, Bolin CA, Reis MG, Riley LW, Haake DA, Ko AI. Pathogenic Leptospira species express surface‐exposed proteins belonging to the bacterial immunoglobulin superfamily. Molecular Microbiology 2003, 49: 929-946. PMID: 12890019, PMCID: PMC1237129, DOI: 10.1046/j.1365-2958.2003.03619.x.Peer-Reviewed Original ResearchConceptsLig proteinsMammalian cell invasionLambda phage clonesLipoprotein signal peptideYersinia pseudotuberculosis invasinSurface-exposed proteinsBacterial immunoglobulin-like domainImmunoglobulin-like domainsHost cell attachmentLeptospira speciesImmunocytochemical electron microscopySurface-expressed proteinsDomain proteinsSaprophytic Leptospira speciesDomain repeatsLeptospiral pathogenesisRNA transcript expressionSignal peptideLig geneLigB genesHost infectionExpression libraryPathogenic Leptospira speciesTandem repeatsBacterial immunoglobulin
2001
Leptospiral Proteins Recognized during the Humoral Immune Response to Leptospirosis in Humans
Guerreiro H, Croda J, Flannery B, Mazel M, Matsunaga J, Reis M, Levett P, Ko A, Haake D. Leptospiral Proteins Recognized during the Humoral Immune Response to Leptospirosis in Humans. Infection And Immunity 2001, 69: 4958-4968. PMID: 11447174, PMCID: PMC98588, DOI: 10.1128/iai.69.8.4958-4968.2001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BacterialAntigens, BacterialBacterial ProteinsCell FractionationElectrophoresis, Gel, Two-DimensionalHumansLeptospiraLeptospirosisRabbitsConceptsHumoral immune responseImmune responseNatural infectionLeptospiral proteinsInfection-associated antigenConvalescent-phase seraPositive reactionConvalescent phaseHumoral responseHealthy individualsHuman leptospirosisControl individualsVaccine designImmunodominant antigensQuantitative immunoblot analysisTwo-dimensional immunoblotsProtein antigensPathogenic leptospiral strainsGenus LeptospiraInfectionAntigenLeptospirosisSerumImmunodominant proteinsPatients