Assessment of Validity of a Blood-Based 3-Gene Signature Score for Progression and Diagnosis of Tuberculosis, Disease Severity, and Treatment Response
Warsinske H, Rao A, Moreira F, Santos P, Liu A, Scott M, Malherbe S, Ronacher K, Walzl G, Winter J, Sweeney T, Croda J, Andrews J, Khatri P. Assessment of Validity of a Blood-Based 3-Gene Signature Score for Progression and Diagnosis of Tuberculosis, Disease Severity, and Treatment Response. JAMA Network Open 2018, 1: e183779. PMID: 30646264, PMCID: PMC6324428, DOI: 10.1001/jamanetworkopen.2018.3779.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntitubercular AgentsBrazilChildCohort StudiesDisease ProgressionFemaleGenes, BacterialGenetic MarkersHumansLatent TuberculosisMaleMiddle AgedMolecular TypingMycobacterium tuberculosisReal-Time Polymerase Chain ReactionReproducibility of ResultsRNA, BacterialSeverity of Illness IndexTuberculosisYoung AdultConceptsTB scoreAdolescent cohort studyNegative predictive valueTreatment responseTB diseaseCohort studyTuberculosis infectionTriage testPositron emission tomography-computed tomography scanPredictive valueLatent M tuberculosis infectionLatent Mycobacterium tuberculosis infectionPrimary health care clinicsHigh negative predictive valueCulture-positive adultsM tuberculosis infectionWhole bloodMycobacterium tuberculosis infectionEnd of treatmentHealth care clinicsCase-control studyIndependent prospective cohortsDiagnosis of tuberculosisSlower treatment responseCase-control cohortSerum vitamin D levels and risk of prevalent tuberculosis, incident tuberculosis and tuberculin skin test conversion among prisoners
Maceda EB, Gonçalves C, Andrews JR, Ko AI, Yeckel CW, Croda J. Serum vitamin D levels and risk of prevalent tuberculosis, incident tuberculosis and tuberculin skin test conversion among prisoners. Scientific Reports 2018, 8: 997. PMID: 29343733, PMCID: PMC5772514, DOI: 10.1038/s41598-018-19589-3.Peer-Reviewed Original ResearchConceptsVitamin D levelsTuberculin skin test conversionPoor vitamin D statusSkin test conversionVitamin D statusActive tuberculosisRisk of progressionCase-control studyD levelsRisk factorsTST conversionD statusCigarette smokingTest conversionSerum vitamin D levelsSubnormal vitamin D levelsMultivariable conditional logistic regressionConditional logistic regressionConsequence of diseaseIncident tuberculosisActive diseaseLatent tuberculosisPrevalent tuberculosisVitamin DBlack race