2020
Antimicrobial activity of plant extracts against carbapenem-producing Klebsiella pneumoniae and in vivo toxicological assessment
Vasconcelos N, Vaz M, Radai J, Kassuya C, Formagio A, Graciani F, Leal M, Oliveira R, da Silva K, Croda J, Simionatto S. Antimicrobial activity of plant extracts against carbapenem-producing Klebsiella pneumoniae and in vivo toxicological assessment. Journal Of Toxicology And Environmental Health Part A 2020, 83: 719-729. PMID: 32981476, DOI: 10.1080/15287394.2020.1824135.Peer-Reviewed Original ResearchConceptsSwiss male miceMultidrug-resistant strainsSplenic phagocytosisMale miceAgar disk diffusionBeneficial effectsToxicological assessmentMicronucleus assayKlebsiella pneumoniaePlant extractsVivo toxicological assessmentDisk diffusionAntibioticsAntimicrobial activityMutagenic activityGlobal spreadExtractMolecular characterizationAssessmentAntibacterial activityActivityMiceActive productsSynergismRisk factors for polymyxin-resistant carbapenemase-producing Enterobacteriaceae in critically ill patients: An epidemiological and clinical study
da Silva K, Baker S, Croda J, Nguyen T, Boinett C, Barbosa L, Tetila A, Simionatto S. Risk factors for polymyxin-resistant carbapenemase-producing Enterobacteriaceae in critically ill patients: An epidemiological and clinical study. International Journal Of Antimicrobial Agents 2020, 55: 105882. PMID: 31923570, DOI: 10.1016/j.ijantimicag.2020.105882.Peer-Reviewed Original ResearchConceptsRisk factorsPolymyxin-resistant strainsNeonatal patientsMortality rateNeonatal intensive care unitEnterobacteriaceae strainsOnly risk factorCentral venous cathetersIntensive care unitCase-control studyPotential risk factorsHigh mortality ratePolymyxin-susceptible strainsCarbapenemase-producing EnterobacteriaceaeCarbapenem exposureAdult patientsAminoglycoside useCarbapenem useRenal failureVenous cathetersIll patientsCare unitUnfavourable outcomePolymerase chain reactionUrinary catheterAntibacterial activity of Cinnamomum cassia L. essential oil in a carbapenem- and polymyxin-resistant Klebsiella aerogenes strain
Vasconcelos N, Silva K, Croda J, Simionatto S. Antibacterial activity of Cinnamomum cassia L. essential oil in a carbapenem- and polymyxin-resistant Klebsiella aerogenes strain. Revista Da Sociedade Brasileira De Medicina Tropical 2020, 53: e20200032. PMID: 33027413, PMCID: PMC7534965, DOI: 10.1590/0037-8682-0032-2020.Peer-Reviewed Original ResearchConceptsHigh antibiotic resistanceMultidrug resistance profilesTime-kill methodsBla OXA-1Multidrug-resistant bacteriaMinimum inhibitory concentrationBla TEMBla CTXAntibacterial activityInhibitory effectBroth microdilutionInhibitory concentrationAntibiotic resistanceK. aerogenesOXA-1KPC-2CarbapenemsCinnamomum cassia essential oilL. essential oilCassia essential oilEssential oilCTXActivity
2019
Origanum vulgare L. essential oil inhibits the growth of carbapenem-resistant gram-negative bacteria
Vasconcelos N, Croda J, Silva K, Motta M, Maciel W, Limiere L, Simionatto S. Origanum vulgare L. essential oil inhibits the growth of carbapenem-resistant gram-negative bacteria. Revista Da Sociedade Brasileira De Medicina Tropical 2019, 52: e20180502. PMID: 31271619, DOI: 10.1590/0037-8682-0502-2018.Peer-Reviewed Original ResearchConceptsCarbapenem-resistant strainsAlternative therapeutic optionTime-kill assaysMultidrug-resistant bacteriaTherapeutic optionsMinimum inhibitory concentrationAcinetobacter baumanniiCell countCarbapenemase productionKill assaysOriganum vulgare L. essential oilL. essential oilKlebsiella pneumoniaeInhibitory concentrationDrug developmentResistant bacteriaH treatmentSerratia marcescensAntimicrobial effectNegative bacteria
2017
Clonal spread of carbapenem-resistant Acinetobacter baumannii in a neonatal intensive care unit
Maciel W, da Silva K, Croda J, Cayô R, Ramos A, de Sales R, Souza G, Bampi J, Limiere L, Casagrande J, Gales A, Simionatto S. Clonal spread of carbapenem-resistant Acinetobacter baumannii in a neonatal intensive care unit. Journal Of Hospital Infection 2017, 98: 300-304. PMID: 29107079, DOI: 10.1016/j.jhin.2017.10.015.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitIntensive care unitCare unitCRAB isolatesAcinetobacter baumanniiStrict infection control measuresCarbapenem-resistant Acinetobacter baumanniiInfection control measuresClonal spreadΒ-lactam therapyPremature newbornsStudy hospitalPeripheral accessClonal typesPolymyxin BBaumanniiSuch isolatesNewbornsControl measuresIsolatesHospitalTherapyInfection
2015
Coproduction of KPC-2 and IMP-10 in Carbapenem-Resistant Serratia marcescens Isolates from an Outbreak in a Brazilian Teaching Hospital
Silva K, Cayô R, Carvalhaes C, Sacchi F, Rodrigues-Costa F, da Silva A, Croda J, Gales A, Simionatto S. Coproduction of KPC-2 and IMP-10 in Carbapenem-Resistant Serratia marcescens Isolates from an Outbreak in a Brazilian Teaching Hospital. Journal Of Clinical Microbiology 2015, 53: 2324-2328. PMID: 25878341, PMCID: PMC4473237, DOI: 10.1128/jcm.00727-15.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnti-Bacterial AgentsBeta-Lactam ResistanceBeta-LactamasesBrazilCarbapenemsChild, PreschoolCross InfectionDisease OutbreaksDNA, BacterialFemaleGenes, BacterialHospitals, TeachingHumansInfantIntegronsMaleMicrobial Sensitivity TestsMiddle AgedMinocyclineMolecular Sequence DataPlasmidsSequence Analysis, DNASerratia InfectionsSerratia marcescensTigecycline