Toxicological analysis and efficacy of 2-phenylchromone on mycobacteria viability and inflammatory response induced by Mycobacterium bovis
Moreira F, Radai J, de Souza V, Berno C, de Araújo F, Andrade-Silva M, Oliveira R, Arena A, de Oliveira Henriques M, Kassuya C, Croda J. Toxicological analysis and efficacy of 2-phenylchromone on mycobacteria viability and inflammatory response induced by Mycobacterium bovis. Phytomedicine Plus 2021, 1: 100117. DOI: 10.1016/j.phyplu.2021.100117.Peer-Reviewed Original ResearchInflammatory responseOral treatmentSplenic phagocytosisTumor necrosis factor levelsAnti-inflammatory actionNecrosis factor levelsAcute oral toxicity testAnti-inflammatory propertiesMycobacterium bovisMycobacterium tuberculosis strainsDifferential leukocyte countsOral toxicity testPleurisy inductionCytokine productionPleurisy modelLeukocyte countMinimum inhibitory concentrationMycobacteria infectionMycobacteria viabilityPleural exudatesLeukocyte migrationTuberculosis strainsVivo modelToxicity signsFactor levelsAnti-inflammatory properties of ethanolic extract from Vatairea macrocarpa leaves
Santos E, Silva-Filho S, Santos Radai J, Arena A, Fraga T, Lima Cardoso C, Croda J, Leite Kassuya C. Anti-inflammatory properties of ethanolic extract from Vatairea macrocarpa leaves. Journal Of Ethnopharmacology 2021, 278: 114308. PMID: 34102271, DOI: 10.1016/j.jep.2021.114308.Peer-Reviewed Original ResearchConceptsAnti-inflammatory propertiesMethylthiazolyldiphenyl-tetrazolium bromideComplete Freund's adjuvantAnti-inflammatory featuresEthanolic extractLong-term treatmentBacillus Calmette-GuerinInflammatory evaluationInflammatory parametersConventional medicationsDaily administrationNeutrophil activityPersistent inflammationRheumatic diseasesFreund's adjuvantInflammatory aspectsPleurisy modelTraditional folk medicineSwiss miceCalmette-GuerinInflammatory diseasesC57BL6 miceVivo modelExperimental modelAdverse effects