2019
Severe Leptospirosis Features in the Spleen Indicate Cellular Immunosuppression Similar to That Found in Septic Shock
Duarte-Neto A, Croda J, Pagliari C, Soriano F, Nicodemo A, Duarte M. Severe Leptospirosis Features in the Spleen Indicate Cellular Immunosuppression Similar to That Found in Septic Shock. Frontiers In Immunology 2019, 10: 920. PMID: 31114579, PMCID: PMC6503108, DOI: 10.3389/fimmu.2019.00920.Peer-Reviewed Original ResearchConceptsSeptic shockLeptospirosis patientsSevere leptospirosisPulmonary hemorrhagePositive cellsRed pulpBacterial septic shockSeptic shock patientsCaspase-3-positive cellsImmune cell markersSpleen of patientsActive caspase-3 positive cellsSemi-quantitative scoreImmunomodulatory treatmentShock patientsCellular immunosuppressionIL-10Immunologic featuresImmunosuppressive stateMarked atrophyEndothelial activationControl spleensHistological featuresIntense infiltrationPlasma cells
2016
Limonene reduces hyperalgesia induced by gp120 and cytokines by modulation of IL-1 β and protein expression in spinal cord of mice
Piccinelli A, Morato P, dos Santos Barbosa M, Croda J, Sampson J, Kong X, Konkiewitz E, Ziff E, Amaya-Farfan J, Kassuya C. Limonene reduces hyperalgesia induced by gp120 and cytokines by modulation of IL-1 β and protein expression in spinal cord of mice. Life Sciences 2016, 174: 28-34. PMID: 27888114, DOI: 10.1016/j.lfs.2016.11.017.Peer-Reviewed Original ResearchConceptsIL-1βSpinal cordMechanical hyperalgesiaIntrathecal injectionIL-10Electronic von Frey apparatusAbility of gp120SOD expressionAnti-inflammatory actionIL-1β injectionMale Swiss miceIL-1 βIL-1β applicationGp120 administrationGp120 injectionAntihyperalgesic effectIntrathecal administrationMechanical sensitivityPrior administrationCytokine productionSwiss miceBlood samplesSterile salineHyperalgesiaPeripheral increase
2008
Potential immunomodulatory effects of plant lectins in Schistosoma mansoni infection
Reis EA, Athanazio DA, Cavada BS, Teixeira EH, de Paulo Teixeira Pinto V, Carmo TM, Reis A, Trocolli G, Croda J, Harn D, Barral-Netto M, Reis MG. Potential immunomodulatory effects of plant lectins in Schistosoma mansoni infection. Acta Tropica 2008, 108: 160-165. PMID: 18579103, DOI: 10.1016/j.actatropica.2008.05.025.Peer-Reviewed Original ResearchConceptsPatients' peripheral blood mononuclear cellsPeripheral blood mononuclear cellsCytokine productionElevated IL-5 productionTh2-like cytokine responseIL-5 productionSchistosoma mansoni infectionStimulation ex vivoTh2-like responseBlood mononuclear cellsPotential immunomodulatory effectsSoluble egg antigenExperimental murine modelTh2 environmentPBMC supernatantsIL-10Mansoni infectionCytokine responsesEgg antigenImmunomodulatory effectsMononuclear cellsInfected patientsIL-5TNF-alphaLymphocyte stimulator