Characterization of a Novel Gain of Function Glucocorticoid Receptor Knock-in Mouse*
Zhang J, Ge R, Matte-Martone C, Goodwin J, Shlomchik WD, Mamula MJ, Kooshkabadi A, Hardy MP, Geller D. Characterization of a Novel Gain of Function Glucocorticoid Receptor Knock-in Mouse*. Journal Of Biological Chemistry 2008, 284: 6249-6259. PMID: 19017639, PMCID: PMC2649105, DOI: 10.1074/jbc.m807997200.Peer-Reviewed Original ResearchConceptsHuman glucocorticoid receptorStudies of glucocorticoidsAdrenocortical sizeGR altersEndogenous glucocorticoidsACTH levelsAdrenal axisReceptor knockImmunologic studiesWild-type GRMaintenance of homeostasisCorticosterone levelsGlucocorticoid receptorGlucocorticoidsNovel gainPhysiologic functionMicePathological processesMutant GRGC functionBasal regulationVivoGC physiologyHomologous recombinationHuman diseases