2023
Endothelial Dysfunction in Cardiorenal Conditions: Implications of Endothelial Glucocorticoid Receptor-Wnt Signaling
Akhter M, Goodwin J. Endothelial Dysfunction in Cardiorenal Conditions: Implications of Endothelial Glucocorticoid Receptor-Wnt Signaling. International Journal Of Molecular Sciences 2023, 24: 14261. PMID: 37762564, PMCID: PMC10531724, DOI: 10.3390/ijms241814261.Peer-Reviewed Original ResearchConceptsGlucocorticoid receptorEndothelial dysfunctionVascular inflammationEndothelial cellsEndothelial glucocorticoid receptorAnti-inflammatory effectsFatty acid oxidation pathwayDifferent pathological conditionsSuppression of WntRenal diseaseInflammatory cascadeVascular toneNovel therapiesMultiple organsBlood fluidityEndothelial integrityPlatelet aggregationInnermost liningVessel permeabilityBlood vesselsPathological conditionsWnt pathwayInflammationDysfunctionDevastating disease
2019
The Glucocorticoid Receptor in Cardiovascular Health and Disease
Liu B, Zhang TN, Knight JK, Goodwin JE. The Glucocorticoid Receptor in Cardiovascular Health and Disease. Cells 2019, 8: 1227. PMID: 31601045, PMCID: PMC6829609, DOI: 10.3390/cells8101227.Peer-Reviewed Original ResearchConceptsGlucocorticoid receptorGlucocorticoid signalingCardiovascular systemNon-genomic pathwaysClinical outcomesExogenous glucocorticoidsGlucocorticoid treatmentCardiovascular healthCardiovascular diseaseNuclear receptor familyTherapeutic strategiesAnimal modelsSteroid hormone cortisolHormone cortisolPathological conditionsReceptorsDiseaseReceptor familySignalingDistinct gene networksHuman diseasesDirect effectCritical roleInflammationPrognosis