2010
A network approach to assessing cognition in disorders of consciousness(e–Pub ahead of print)(CME)
Rodriguez Moreno D, Schiff N, Giacino J, Kalmar K, Hirsch J. A network approach to assessing cognition in disorders of consciousness(e–Pub ahead of print)(CME). Neurology 2010, 75: 1871-1878. PMID: 20980667, PMCID: PMC2995384, DOI: 10.1212/wnl.0b013e3181feb259.Peer-Reviewed Original ResearchMeSH KeywordsAdultAwarenessBrainCognitionConsciousness DisordersFemaleGlasgow Coma ScaleHumansMagnetic Resonance ImagingMaleMiddle AgedNerve NetNeuropsychological TestsPattern Recognition, VisualPersistent Vegetative StatePoint-of-Care SystemsQuadriplegiaSensitivity and SpecificityVerbal BehaviorYoung AdultConceptsDisorders of consciousnessVegetative stateComa Recovery ScaleHigh-level cognitionObject-naming taskPicture-naming taskLanguage-related regionsElicit brain activationEMCS patientsVS patientsHealthy subjectsDiagnostic criteriaPatientsVolitional processesRecovery ScaleBrain activationLanguage networkFMRI studyMotor responseOvert behaviorConscious stateNeural systemsBehavioral assessmentCognitionPartial preservation
2009
Behavioral assessment in patients with disorders of consciousness: gold standard or fool's gold?
Giacino JT, Schnakers C, Rodriguez-Moreno D, Kalmar K, Schiff N, Hirsch J. Behavioral assessment in patients with disorders of consciousness: gold standard or fool's gold? Progress In Brain Research 2009, 177: 33-48. PMID: 19818893, DOI: 10.1016/s0079-6123(09)17704-x.Peer-Reviewed Original ResearchConceptsDisorders of consciousnessMedication side effectsSevere brain injuryAssessment of patientsBehavioral assessmentCurrent diagnostic criteriaFunctional neuroimaging findingsBrain injuryInvoluntary movementsNeuroimaging findingsMotor impairmentDiagnostic criteriaSide effectsBehavioral assessment techniquesNeurophysiologic markersVegetative stateConscious stateGold standardBehavioral assessment methodsFunctional neuroimagingPatientsDisordersIndirect evidenceBehavioral markersMarkers
2005
fMRI reveals large-scale network activation in minimally conscious patients
Schiff N, Rodriguez-Moreno D, Kamal A, Kim K, Giacino J, Plum F, Hirsch J. fMRI reveals large-scale network activation in minimally conscious patients. Neurology 2005, 64: 514-523. PMID: 15699384, DOI: 10.1212/01.wnl.0000150883.10285.44.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationAdultAttentionAuditory CortexAwarenessCerebral HemorrhageCraniocerebral TraumaEncephalomalaciaFixation, OcularHumansLanguageMagnetic Resonance ImagingMalePersistent Vegetative StatePhysical StimulationSomatosensory CortexTemporal LobeTouchVerbal BehaviorWounds, NonpenetratingConceptsCognitive functionCortical activityLanguage-related tasksResidual cognitive functionMiddle temporal gyrusTactile stimulationMeaningless stimuliActive cortical networkConscious stateLanguage stimulationNeurobiological correlatesLanguage functionTemporal gyrusBehavioral evidenceMCS patientsCortical systemsLinguistic contentAuditory stimulationCortical networksLanguage processingCerebral networksNetwork activationCortical responsesCommunication abilityFMRI maps