2013
Effects of Reduced Weight Maintenance and Leptin Repletion on Functional Connectivity of the Hypothalamus in Obese Humans
Hinkle W, Cordell M, Leibel R, Rosenbaum M, Hirsch J. Effects of Reduced Weight Maintenance and Leptin Repletion on Functional Connectivity of the Hypothalamus in Obese Humans. PLOS ONE 2013, 8: e59114. PMID: 23555620, PMCID: PMC3605420, DOI: 10.1371/journal.pone.0059114.Peer-Reviewed Original ResearchConceptsLeptin repletionRight hypothalamusFunctional connectivityFood cuesWeight lossGreater weight lossOrbital frontal cortexDorsal anterior cingulatePsychophysiological interaction analysisPlacebo injectionsObese subjectsObese populationLeptin injectionObese humansWeight maintenanceFrontal cortexAnterior cingulateHypothalamusFrontal poleInteroceptive systemPatient subjectsVisual areasDorsal ACCFood stimuliRepletion
2010
Energy intake in weight-reduced humans
Rosenbaum M, Kissileff HR, Mayer LE, Hirsch J, Leibel RL. Energy intake in weight-reduced humans. Brain Research 2010, 1350: 95-102. PMID: 20595050, PMCID: PMC2926239, DOI: 10.1016/j.brainres.2010.05.062.Peer-Reviewed Original ResearchConceptsEnergy intakeWeight lossSustained weight lossSuccessful weight reductionAdipocyte-derived hormoneBody weight maintenanceEnergy expenditureBody composition changesBody energy storesWeight maintenanceBody fatnessBody weightNeuronal signalingIntakeWeight reductionBasis of weightEnergy storesMultiple changesLeptinWeightHormoneResponse
2009
Adipose tissue distribution after weight restoration and weight maintenance in women with anorexia nervosa
Mayer L, Klein DA, Black E, Attia E, Shen W, Mao X, Shungu DC, Punyanita M, Gallagher D, Wang J, Heymsfield SB, Hirsch J, Ginsberg HN, Walsh BT. Adipose tissue distribution after weight restoration and weight maintenance in women with anorexia nervosa. American Journal Of Clinical Nutrition 2009, 90: 1132-1137. PMID: 19793856, PMCID: PMC2762154, DOI: 10.3945/ajcn.2009.27820.Peer-Reviewed Original ResearchConceptsAdipose tissue distributionAcute weight restorationControl subjectsWeight maintenanceWeight restorationAdipose tissueAnorexia nervosaTissue distributionControl womenVisceral adipose tissue distributionLong-term weight maintenanceAdult womenWhole-body magnetic resonanceHealthy control subjectsFemale control subjectsHealthy control womenIntermuscular adipose tissueCentral adiposity phenotypeHospital dischargeNormal weightBody compositionNormalization of weightBody image distortionPatientsTime points
2008
Leptin reverses weight loss–induced changes in regional neural activity responses to visual food stimuli
Rosenbaum M, Sy M, Pavlovich K, Leibel RL, Hirsch J. Leptin reverses weight loss–induced changes in regional neural activity responses to visual food stimuli. Journal Of Clinical Investigation 2008, 118: 2583-2591. PMID: 18568078, PMCID: PMC2430499, DOI: 10.1172/jci35055.Peer-Reviewed Original ResearchConceptsMiddle frontal gyrusNeural activityFood cuesFrontal gyrusFood-related visual cuesWeight lossFood intakeWeight loss-induced changesVisual food cuesVisual food stimuliMiddle temporal gyrusRelative leptin deficiencyWeight-reduced stateDaily subcutaneous injectionsBody weight maintenanceCognitive controlFood stimuliTemporal gyrusVisual cuesLeptin deficiencyObese subjectsWeight maintenanceLingual gyrusClinical managementFunctional MRI