2022
Rejection Distress Suppresses Medial Prefrontal Cortex in Borderline Personality Disorder
Fertuck E, Stanley B, Kleshchova O, Mann J, Hirsch J, Ochsner K, Pilkonis P, Erbe J, Grinband J. Rejection Distress Suppresses Medial Prefrontal Cortex in Borderline Personality Disorder. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2022, 8: 651-659. PMID: 36868964, PMCID: PMC10388534, DOI: 10.1016/j.bpsc.2022.11.006.Peer-Reviewed Original ResearchConceptsBorderline personality disorderRejection distressFunctional magnetic resonancePrefrontal cortex responsesCortex responsesPrefrontal cortexPersonality disorderControl participantsWhole-brain responsesNeural responsesFunctional magnetic resonance imagingMagnetic resonance imagingMedial prefrontal cortexHealthy control participantsUnivariate analysisMagnetic resonanceBPD groupResonance imagingNovel functional magnetic resonanceGroup differencesRostromedial prefrontal cortexNeural substratesBrain activityDistressNeural mechanisms
2018
The present and future use of functional near‐infrared spectroscopy (fNIRS) for cognitive neuroscience
Pinti P, Tachtsidis I, Hamilton A, Hirsch J, Aichelburg C, Gilbert S, Burgess PW. The present and future use of functional near‐infrared spectroscopy (fNIRS) for cognitive neuroscience. Annals Of The New York Academy Of Sciences 2018, 1464: 5-29. PMID: 30085354, PMCID: PMC6367070, DOI: 10.1111/nyas.13948.Peer-Reviewed Original ResearchConceptsCognitive neuroscienceSocial cognitive neuroscienceCognitive neuroscience researchFunctional magnetic resonance imagingElectroencephalography/magnetoencephalographyPotential of fNIRSNaturalistic environmentNeuroscience researchNeuroscienceNeuroimaging modalitiesBodily movementParticipant populationExperimental settingsMagnetic resonance imagingFNIRSMagnetoencephalographyResonance imagingParticular focusResearchA Review on the Use of Wearable Functional Near‐Infrared Spectroscopy in Naturalistic Environments
Pinti P, Aichelburg C, Gilbert S, Hamilton A, Hirsch J, Burgess P, Tachtsidis I. A Review on the Use of Wearable Functional Near‐Infrared Spectroscopy in Naturalistic Environments. Japanese Psychological Research 2018, 60: 347-373. PMID: 30643322, PMCID: PMC6329605, DOI: 10.1111/jpr.12206.Peer-Reviewed Original ResearchCognitive neuroscienceFunctional magnetic resonance imagingFunctional Near-Infrared SpectroscopyCognitive research fieldHuman brain functioningEveryday life scenariosFunctional brain activityFunctional brain imagingNeural basisFNIR systemNaturalistic environmentBrain activityBrain functioningNaturalistic settingNeuroimaging modalitiesBrain imagingOverview of studiesHealthy brainNeuroscienceFNIRSNear-Infrared SpectroscopyMagnetic resonance imagingAccurate inferenceLife scenariosFunctioning
2014
Brief Report: Anomalous Neural Deactivations and Functional Connectivity During Receptive Language in Autism Spectrum Disorder: A Functional MRI Study
Karten A, Hirsch J. Brief Report: Anomalous Neural Deactivations and Functional Connectivity During Receptive Language in Autism Spectrum Disorder: A Functional MRI Study. Journal Of Autism And Developmental Disorders 2014, 45: 1905-1914. PMID: 25526952, PMCID: PMC4441908, DOI: 10.1007/s10803-014-2344-y.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderNegative BOLD responseASD participantsReceptive languageLanguage disabilitySpectrum disorderNeural deactivationInhibitory processesFunctional connectivityFunctional magnetic resonance imagingBlood oxygen level-dependent (BOLD) responseSuperior temporal gyrusFunctional MRI studyLevel-dependent responsesNeural mechanismsPassive listeningTemporal gyrusBOLD responseControl participantsParticipantsLanguageMagnetic resonance imagingExcitatory processesMRI studiesConnectivity
2012
Gray Matter Abnormalities in Social Anxiety Disorder: Primary, Replication, and Specificity Studies
Talati A, Pantazatos SP, Schneier FR, Weissman MM, Hirsch J. Gray Matter Abnormalities in Social Anxiety Disorder: Primary, Replication, and Specificity Studies. Biological Psychiatry 2012, 73: 75-84. PMID: 22748614, PMCID: PMC3465490, DOI: 10.1016/j.biopsych.2012.05.022.Peer-Reviewed Original ResearchConceptsControl subjectsAnxiety disordersGray matter abnormalitiesHealthy control groupAge 30 yearsDSM-IV criteriaTotal intracranial volumeVoxel-based morphometryGray matter differencesMagnetic resonance imagingBilateral temporal poleLateral orbitofrontal cortexPanic disorder subjectsAngular cortexPD groupFunctional disturbancesNeuroanatomical abnormalitiesSocial anxiety disorderControl groupTemporal poleStructural abnormalitiesLifetime historyResonance imagingSAD groupIntracranial volumeConceptual representations of perceptual knowledge
Smith EE, Myers N, Sethi U, Pantazatos S, Yanagihara T, Hirsch J. Conceptual representations of perceptual knowledge. Cognitive Neuropsychology 2012, 29: 237-248. PMID: 22994286, PMCID: PMC3516296, DOI: 10.1080/02643294.2012.706218.Peer-Reviewed Original ResearchConceptsInferior frontal gyrusFunctional magnetic resonance imagingFusiform gyrusPerceptual propertiesPerceptual knowledgeLeft inferior frontal gyrusLeft fusiform gyrusMiddle temporal gyrusPerceptual processingAmodal processesModality-specific mannerSemantic memoryBehavioral performanceFrontal gyrusThompson-SchillConceptual representationKan et alVerbal statementsGyrusParticipantsProcessingMagnetic resonance imagingRepresentationBarsalouMemoryRelation between changes in neural responsivity and reductions in desire to eat high-calorie foods following gastric bypass surgery
Ochner C, Stice E, Hutchins E, Afifi L, Geliebter A, Hirsch J, Teixeira J. Relation between changes in neural responsivity and reductions in desire to eat high-calorie foods following gastric bypass surgery. Neuroscience 2012, 209: 128-135. PMID: 22406414, PMCID: PMC3601838, DOI: 10.1016/j.neuroscience.2012.02.030.Peer-Reviewed Original ResearchConceptsLow-calorie food cuesGastric bypass surgeryPostoperative reductionPostoperative changesHigh-calorie foodsBypass surgeryNeural responsivityFood cuesSignificant postoperative reductionReward-related neural activationFunctional magnetic resonance imagingMagnetic resonance imagingDopaminergic reward pathwayLow-calorie foodsObesity surgeryLiking of foodNeural changesReward pathwayResonance imagingOne monthSurgeryRating ScaleInhibitory activationNeural activationRYGBSleep restriction leads to increased activation of brain regions sensitive to food stimuli
St-Onge MP, McReynolds A, Trivedi ZB, Roberts AL, Sy M, Hirsch J. Sleep restriction leads to increased activation of brain regions sensitive to food stimuli. American Journal Of Clinical Nutrition 2012, 95: 818-824. PMID: 22357722, PMCID: PMC3302360, DOI: 10.3945/ajcn.111.027383.Peer-Reviewed Original ResearchConceptsFood stimuliNeuronal activityHabitual sleepSleep restrictionNormal-weight menOverall neuronal activityAverage sleep durationFunctional magnetic resonance imagingMagnetic resonance imagingPartial sleep restrictionCrossover studyEpidemiologic evidenceClinical studiesNeuronal activationNucleus accumbensSleep durationFasted stateResonance imagingBrain regionsDay 6Prefrontal cortexSleepBrain activityRelative increaseStimuli
2011
Can Depression be Diagnosed by Response to Mother's Face? A Personalized Attachment-Based Paradigm for Diagnostic fMRI
Zhang X, Yaseen ZS, Galynker II, Hirsch J, Winston A. Can Depression be Diagnosed by Response to Mother's Face? A Personalized Attachment-Based Paradigm for Diagnostic fMRI. PLOS ONE 2011, 6: e27253. PMID: 22180777, PMCID: PMC3236742, DOI: 10.1371/journal.pone.0027253.Peer-Reviewed Original ResearchConceptsBDI-II scoresFunctional magnetic resonance imagingBeck Depression Inventory-IIMagnetic resonance imagingResonance imagingInventory-IIBeck Depression Inventory-II scoresMINI psychiatric interviewII scoreDepression diagnosisPsychiatric interviewBA 32Paracingulate gyrusDepressed subjectsActivity patternsClinical diagnosisBrain reactivitySensitivity 85.7Diagnostic algorithmFemale subjectsDepressionSpecificity 92.8FMRI imagingScoresBrain activityDifferences in Regional Brain Activation Patterns Assessed by Functional Magnetic Resonance Imaging in Patients with Systemic Lupus Erythematosus Stratified by Disease Duration
Mackay M, Bussa MP, Aranow C, Uluğ AM, Volpe BT, Huerta PT, Argyelan M, Mandel A, Hirsch J, Diamond B, Eidelberg D. Differences in Regional Brain Activation Patterns Assessed by Functional Magnetic Resonance Imaging in Patients with Systemic Lupus Erythematosus Stratified by Disease Duration. Molecular Medicine 2011, 17: 1349-1356. PMID: 21953419, PMCID: PMC3321819, DOI: 10.2119/molmed.2011.00185.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusBlood-brain barrierFunctional magnetic resonance imagingTissue damageDisease durationBrain activation patternsLupus erythematosusST groupSystemic Lupus International Collaborating Clinics Damage IndexActivation patternsFearful face paradigmRegional brain activation patternsDuration of diseaseRegional brain abnormalitiesCentral nervous systemMagnetic resonance imagingFunctional magnetic resonanceCorticosteroid dosesDisease activityComorbid diseasesSLE patientsImmune cellsVascular diseaseBrain injuryBrain abnormalitiesSelective Reduction in Neural Responses to High Calorie Foods Following Gastric Bypass Surgery
Ochner CN, Kwok Y, Conceição E, Pantazatos SP, Puma LM, Carnell S, Teixeira J, Hirsch J, Geliebter A. Selective Reduction in Neural Responses to High Calorie Foods Following Gastric Bypass Surgery. Annals Of Surgery 2011, 253: 502-507. PMID: 21169809, PMCID: PMC3128512, DOI: 10.1097/sla.0b013e318203a289.Peer-Reviewed Original ResearchConceptsRYGB surgeryHigh-calorie foodsPostsurgical reductionFood cuesCaloric intakeLow-calorie food cuesCommon bariatric proceduresPost-RYGB surgeryGastric bypass surgeryBrain activationNeural activationVerbal rating scaleCaloric densityNeural responsesMesolimbic reward pathwayFunctional magnetic resonance imagingMagnetic resonance imagingMechanism of actionMalabsorptive mechanismsBariatric proceduresGastric bypassBypass surgeryFemale patientsGut peptidesPostbariatric surgery
2009
Effects of heartbeat and respiration on macaque fMRI: Implications for functional connectivity
Teichert T, Grinband J, Hirsch J, Ferrera VP. Effects of heartbeat and respiration on macaque fMRI: Implications for functional connectivity. Neuropsychologia 2009, 48: 1886-1894. PMID: 19969009, PMCID: PMC2876227, DOI: 10.1016/j.neuropsychologia.2009.11.026.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingFunctional connectivityRespiratory artifactsAnesthetized macaque monkeysMagnetic resonance imagingNon-human primatesAwake humansMacaque monkeysResonance imagingFalse negative correlationNeuronal energy consumptionEffect of heartbeatNegative correlationAdequate replacementRespiratory activityNeural circuitry of submissive behavior in social anxiety disorder: A preliminary study of response to direct eye gaze
Schneier FR, Kent JM, Star A, Hirsch J. Neural circuitry of submissive behavior in social anxiety disorder: A preliminary study of response to direct eye gaze. Psychiatry Research 2009, 173: 248-250. PMID: 19628377, PMCID: PMC2745296, DOI: 10.1016/j.pscychresns.2008.06.004.Peer-Reviewed Original ResearchConceptsSocial anxiety disorderEye gazeAnxiety disordersPathophysiology of SADSubmissive behaviorFunctional magnetic resonance imagingDirect eye gazeAverted gazeDirect gazeNeural responsesPrefrontal cortexSAD subjectsAnterior cingulateNeural circuitryNeural activityBrain regionsGazeMagnetic resonance imagingHealthy volunteersResonance imagingDisordersInsulaCingulateFearSignificant differences
2007
Repeated Exposure to Media Violence Is Associated with Diminished Response in an Inhibitory Frontolimbic Network
Kelly CR, Grinband J, Hirsch J. Repeated Exposure to Media Violence Is Associated with Diminished Response in an Inhibitory Frontolimbic Network. PLOS ONE 2007, 2: e1268. PMID: 18060062, PMCID: PMC2092389, DOI: 10.1371/journal.pone.0001268.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingRight lateral orbitofrontal cortexMagnetic resonance imagingLateral orbitofrontal cortexDiminished responsivenessDiminished responseShort-term exposureResonance imagingFrontolimbic networkOrbitofrontal cortexCortical networksNovel findingsExposureResponseCortexBrain Activity Associated With Stimulation Therapy of the Visual Borderzone in Hemianopic Stroke Patients
Marshall RS, Ferrera JJ, Barnes A, Xian Zhang, O'Brien KA, Chmayssani M, Hirsch J, Lazar RM. Brain Activity Associated With Stimulation Therapy of the Visual Borderzone in Hemianopic Stroke Patients. Neurorehabilitation And Neural Repair 2007, 22: 136-144. PMID: 17698955, DOI: 10.1177/1545968307305522.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAdultAgedAttentionBrainBrain MappingCerebrovascular CirculationFemaleFunctional LateralityHemianopsiaHumansMagnetic Resonance ImagingMaleMiddle AgedNeuronal PlasticityPhotic StimulationPhysical Therapy ModalitiesStrokeTreatment OutcomeVisual PathwaysVisual PerceptionConceptsVisual restoration therapyRestoration therapyHemianopic patientsAnterior cingulateHemianopic stroke patientsHigher-order visual areasBilateral anterior cingulateBilateral basal gangliaHome-based treatment programDorsolateral frontal cortexBlood oxygen level-dependent activityBrain activityFunctional magnetic resonance imagingMagnetic resonance imagingBrain Activity AssociatedCondition interactionLevel-dependent activityStroke patientsBasal gangliaBrain injuryStimulation therapyFrontal cortexMiddle temporal regionsRepetitive stimulationVisual therapy
2006
Resolving Emotional Conflict: A Role for the Rostral Anterior Cingulate Cortex in Modulating Activity in the Amygdala
Etkin A, Egner T, Peraza DM, Kandel ER, Hirsch J. Resolving Emotional Conflict: A Role for the Rostral Anterior Cingulate Cortex in Modulating Activity in the Amygdala. Neuron 2006, 51: 871-882. PMID: 16982430, DOI: 10.1016/j.neuron.2006.07.029.Peer-Reviewed Original ResearchConceptsRostral anterior cingulate cortexAnterior cingulate cortexFunctional magnetic resonance imagingCingulate cortexEmotional conflictAmygdalar activityRostral cingulate cortexMagnetic resonance imagingDorsolateral prefrontal cortexRostral cingulateResonance imagingPrefrontal cortexModulating activityCortexConflict taskSalient stimuliNeural activityNeural mechanismsMental functioningActivationConflictActivityAmygdalaCortical Activation While Watching Video Montage: An fMRI Study
Anderson D, Fite K, Petrovich N, Hirsch J. Cortical Activation While Watching Video Montage: An fMRI Study. Media Psychology 2006, 8: 7-24. DOI: 10.1207/s1532785xmep0801_2.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingHemisphere language areasMultiple brain areasLanguage areasAction sequencesPosterior cingulateLeft hemisphere language areasCortical networksHigher-level cognitive networksBrain areasRight hemisphere homologueFlow of actionsCognitive activityFMRI studyVisual actionsRight hemisphereCortical activationFrontal areasCoordinated activityCognitive networksVideo montageCingulateMagnetic resonance imagingExtrastriateComprehension
1999
Brain Mapping in Sedated Infants and Young Children with Passive-Functional Magnetic Resonance Imaging
Souweidane M, Kim K, McDowall R, Ruge M, Lis E, Krol G, Hirsch J. Brain Mapping in Sedated Infants and Young Children with Passive-Functional Magnetic Resonance Imaging. Pediatric Neurosurgery 1999, 30: 86-92. PMID: 10325564, DOI: 10.1159/000028768.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMagnetic resonance imagingSedated childrenResonance imagingBrain mappingDiagnostic MRI scanYoung childrenLevel-dependent signalEarly developmental statusPediatric patientsPatient complianceMRI scansSedated infantsCortical regionsPatient interactionsFMRI techniquesFrequent needFMRI procedureLanguage functionChildrenInfantsDevelopmental statusPassive stimuliImagingStandard techniquesConcordance between Functional Magnetic Resonance Imaging and Intraoperative Language Mapping
Ruge M, Victor J, Hosain S, Correa D, Relkin N, Tabar V, Brennan C, Gutin P, Hirsch J. Concordance between Functional Magnetic Resonance Imaging and Intraoperative Language Mapping. Stereotactic And Functional Neurosurgery 1999, 72: 95-102. PMID: 10853058, DOI: 10.1159/000029706.Peer-Reviewed Original ResearchConceptsDirect cortical stimulationIntraoperative electrophysiologyCortical stimulationSensorimotor cortexIntraoperative language mappingFunctional magnetic resonance imagingMagnetic resonance imagingSSEP recordingsLocalization of functionMotor cortexIntraoperative localizationPreoperative toolResonance imagingLanguage mappingCortexWernicke's areaElectrophysiologyFMRIPresent studyStimulationSensorimotor mappingConcordancePatientsBroca
1997
Distinct cortical areas associated with native and second languages
Kim K, Relkin N, Lee K, Hirsch J. Distinct cortical areas associated with native and second languages. Nature 1997, 388: 171-174. PMID: 9217156, DOI: 10.1038/40623.Peer-Reviewed Original ResearchConceptsSecond languageFunctional magnetic resonance imagingMultiple language functionsLanguage-specific regionsCortical areasEssential human capacitiesFrontal cortical areasLanguage acquisitionNative languageBilingual subjectsMultiple languagesDistinct cortical areasLanguageLanguage functionBroca's areaCortical representationHuman capacityHuman brainHuman cortexAcquisition stageSeparation of activitiesMagnetic resonance imagingResonance imagingFundamental questionsAdulthood