2021
PIWI-mediated control of tissue-specific transposons is essential for somatic cell differentiation
Li D, Taylor D, van Wolfswinkel J. PIWI-mediated control of tissue-specific transposons is essential for somatic cell differentiation. Cell Reports 2021, 37: 109776. PMID: 34610311, PMCID: PMC8532177, DOI: 10.1016/j.celrep.2021.109776.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArgonaute ProteinsCell DifferentiationChromatinChromatin Assembly and DisassemblyDNA Transposable ElementsHelminth ProteinsIntestinesPlanariansPluripotent Stem CellsRNA InterferenceRNA, Small InterferingConceptsPIWI-interacting RNAsPIWI proteinsCell differentiationDefective cell differentiationLineage-specific genesSubset of transposonsAdult pluripotent stem cellsSomatic cell differentiationStem cell systemStem cell biologyPluripotent stem cellsTransposon derepressionAnimal germlineSpecific chromatinRegenerative animalsPlanarian neoblastsCell biologyTransposonStem cellsProteinDifferentiationIntricate interplayCell systemAddition causesTissue dysfunction
2010
The role of small non-coding RNAs in genome stability and chromatin organization
van Wolfswinkel JC, Ketting RF. The role of small non-coding RNAs in genome stability and chromatin organization. Journal Of Cell Science 2010, 123: 1825-1839. PMID: 20484663, DOI: 10.1242/jcs.061713.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChromatin Assembly and DisassemblyDNA MethylationGene Expression RegulationGenomic InstabilityHistonesHumansMicroRNAsConceptsSmall non-coding RNAsNon-coding RNAsSmall-interfering RNAChromatin-related mechanismsPost-transcriptional regulationNew regulatory mechanismNon-coding RNAChromatin regulationGenome stabilityChromatin organizationRegulatory potentialGene expressionRegulatory mechanismsRNARNA contentInitial discoveryRegulationEukaryotesMicroRNAsMechanismExpressionCellsDiscovery