2021
PIWI-mediated control of tissue-specific transposons is essential for somatic cell differentiation
Li D, Taylor D, van Wolfswinkel J. PIWI-mediated control of tissue-specific transposons is essential for somatic cell differentiation. Cell Reports 2021, 37: 109776. PMID: 34610311, PMCID: PMC8532177, DOI: 10.1016/j.celrep.2021.109776.Peer-Reviewed Original ResearchConceptsPIWI-interacting RNAsPIWI proteinsCell differentiationDefective cell differentiationLineage-specific genesSubset of transposonsAdult pluripotent stem cellsSomatic cell differentiationStem cell systemStem cell biologyPluripotent stem cellsTransposon derepressionAnimal germlineSpecific chromatinRegenerative animalsPlanarian neoblastsCell biologyTransposonStem cellsProteinDifferentiationIntricate interplayCell systemAddition causesTissue dysfunction
2014
Single-Cell Analysis Reveals Functionally Distinct Classes within the Planarian Stem Cell Compartment
van Wolfswinkel JC, Wagner DE, Reddien PW. Single-Cell Analysis Reveals Functionally Distinct Classes within the Planarian Stem Cell Compartment. Cell Stem Cell 2014, 15: 326-339. PMID: 25017721, PMCID: PMC4171737, DOI: 10.1016/j.stem.2014.06.007.Peer-Reviewed Original ResearchConceptsSingle-cell transcriptional profilingDistinct cellular compartmentsGene expression fingerprintPluripotent stem cellsStem cell compartmentProliferative cell populationDistinct classesTranscriptional profilingCellular compartmentsPlanarian neoblastsExpression fingerprintsBroad lineagesEpidermal cellsNeoblastsStem cellsCell compartmentLineagesCell populationsCell analysisCellsCompartmentsPlanariansFlatwormsRegenerationHomeostasis