2011
Parathyroid Hormone-Related Protein Is Not Required for Normal Ductal or Alveolar Development in the Post-Natal Mammary Gland
Boras-Granic K, VanHouten J, Hiremath M, Wysolmerski J. Parathyroid Hormone-Related Protein Is Not Required for Normal Ductal or Alveolar Development in the Post-Natal Mammary Gland. PLOS ONE 2011, 6: e27278. PMID: 22087279, PMCID: PMC3210770, DOI: 10.1371/journal.pone.0027278.Peer-Reviewed Original ResearchConceptsMammary glandPTHrP expressionAlveolar developmentMyoepithelial cellsMaternal calcium homeostasisOverexpression of PTHrPRole of PTHrPExpression of PTHrPEmbryonic mammary budPTHrP deficiencyMouse mammary glandParathyroid hormoneTransgenic miceDuctal developmentCalcium homeostasisAlveolar cellsPTHrPPubertal developmentMMTV-CrePost-natal mammary glandMammary developmentMammary budPostnatal mammary glandCre transgenePTHrP gene
2005
The calcium-sensing receptor regulates PTHrP production and calcium transport in the lactating mammary gland
Ardeshirpour L, Dann P, Pollak M, Wysolmerski J, VanHouten J. The calcium-sensing receptor regulates PTHrP production and calcium transport in the lactating mammary gland. Bone 2005, 38: 787-793. PMID: 16377269, DOI: 10.1016/j.bone.2005.11.009.Peer-Reviewed Original ResearchConceptsCalcium-sensing receptorPTHrP productionMammary epithelial cellsMammary glandCalcium transportEpithelial cellsCalcium homeostasisParathyroid hormone-related proteinParathyroid hormone secretionProduction of PTHrPHormone-related proteinSystemic calcium homeostasisExtracellular calcium ionsTransepithelial calcium transportG protein-coupled receptorsHormone secretionParathyroid glandsBone massCalcium handlingRenal tubulesTransient lossGlandGenetic confirmationReceptorsSecretionMaternal calcium and bone metabolism during lactation
VanHouten J. Maternal calcium and bone metabolism during lactation. Current Opinion In Endocrinology Diabetes And Obesity 2005, 12: 477-482. DOI: 10.1097/01.med.0000185780.49783.84.Peer-Reviewed Original ResearchParathyroid hormone-related proteinHormone-related proteinMaternal bone mineral densityBone mineral densityCalcium-sensing receptorBone metabolismMammary glandMineral densityParathyroid hormone-related protein levelsMaternal bone metabolismMaternal calcium homeostasisLow estrogen levelsPurpose of reviewParathyroid hormone-related protein geneMaternal calciumEstrogen deficiencyBone lossEstrogen levelsEstrogen treatmentParathyroid glandsMammary epithelial cellsCalcium homeostasisSkeletal calciumSelective deletionTransient lossCalcium Sensing by the Mammary Gland
VanHouten JN. Calcium Sensing by the Mammary Gland. Journal Of Mammary Gland Biology And Neoplasia 2005, 10: 129-139. PMID: 16025220, DOI: 10.1007/s10911-005-5396-y.Peer-Reviewed Original ResearchConceptsMammary glandExtracellular calcium-sensing receptorMaternal calcium homeostasisOsteolytic bone metastasesCalcium-sensing receptorHormone-related proteinNeoplastic mammary epithelial cellsBreast cancer cellsBone metastasesMammary epithelial cellsCalcium homeostasisCalcium fluxEpithelial cellsMilk secretionCancer cellsCalcium sensingImportant entityGlandCellsMetastasisPTHrPSecretionReceptors
2003
Low Estrogen and High Parathyroid Hormone-Related Peptide Levels Contribute to Accelerated Bone Resorption and Bone Loss in Lactating Mice
VanHouten JN, Wysolmerski JJ. Low Estrogen and High Parathyroid Hormone-Related Peptide Levels Contribute to Accelerated Bone Resorption and Bone Loss in Lactating Mice. Endocrinology 2003, 144: 5521-5529. PMID: 14500568, DOI: 10.1210/en.2003-0892.Peer-Reviewed Original ResearchConceptsBone lossBone mineral densityBone resorptionMineral densityDual-energy X-ray absorptiometryBone resorption markersX-ray absorptiometryRegulation of calciumAge-matched virginsPamidronate treatmentPTHrP levelsResorption markersLow estrogenEstrogen deficiencyBone turnoverEstrogen levelsPregnant miceBone metabolismBone massPeptide levelsSkeletal metabolismTotal bodyBone volumeCalcium homeostasisBiochemical markers