2014
Doppler abnormalities in monochorionic diamniotic twin pregnancies with discordant growth
Zuckerwise L, Nayeri U, Abdel-Razeq S, Copel J, Bahtiyar M. Doppler abnormalities in monochorionic diamniotic twin pregnancies with discordant growth. Journal Of Perinatology 2014, 35: 387-389. PMID: 25521562, DOI: 10.1038/jp.2014.223.Peer-Reviewed Original ResearchConceptsDoppler flow velocity waveformsFlow velocity waveformsDiscordant growthVelocity waveformsTwin gestationsSmall fetusesAbnormal umbilical artery Doppler flow velocity waveformsUmbilical artery Doppler flow velocity waveformsMonochorionic diamniotic twin gestationsMonochorionic diamniotic twin pregnanciesNeonatal intensive care unitDiamniotic twin gestationsMCDA twin pairsDiamniotic twin pregnanciesEnd-diastolic flowLow Apgar scoreBirth weight discordanceDiscordant fetal growthIntensive care unitTwin transfusion syndromeDoppler velocity waveformsT-testElectronic medical recordsTwin pairsStudent's t-test
2009
Prospective Evaluation of Fetuses With Autoimmune-Associated Congenital Heart Block Followed in the PR Interval and Dexamethasone Evaluation (PRIDE) Study
Friedman DM, Kim MY, Copel JA, Llanos C, Davis C, Buyon JP. Prospective Evaluation of Fetuses With Autoimmune-Associated Congenital Heart Block Followed in the PR Interval and Dexamethasone Evaluation (PRIDE) Study. The American Journal Of Cardiology 2009, 103: 1102-1106. PMID: 19361597, PMCID: PMC2730772, DOI: 10.1016/j.amjcard.2008.12.027.Peer-Reviewed Original ResearchConceptsThird-degree blockSecond-degree blockCongenital heart blockFirst-degree blockDEX groupHeart blockAutoimmune-Associated Congenital Heart BlockEfficacy of dexamethasoneSteroid side effectsNormal sinus rhythmMedian ventricular ratesCardiac dysfunctionGestational ageVentricular rateNonrandomized studyProspective evaluationSinus rhythmGrowth restrictionPR intervalPacemaker useRare caseTherapeutic benefitSide effectsBirth ageDexamethasone
2008
Stillbirth at Term in Women of Advanced Maternal Age in the United States: When Could the Antenatal Testing Be Initiated?
Bahtiyar M, Funai E, Rosenberg V, Norwitz E, Lipkind H, Buhimschi C, Copel J. Stillbirth at Term in Women of Advanced Maternal Age in the United States: When Could the Antenatal Testing Be Initiated? American Journal Of Perinatology 2008, 25: 301-304. PMID: 18437644, DOI: 10.1055/s-2008-1076605.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultFemaleFetal DeathHumansMaternal AgeRisk FactorsStillbirthTerm BirthUnited StatesConceptsIntrauterine fetal demiseAdvanced maternal ageYears of ageRisk of IUFDAntenatal testingMaternal ageSingleton term deliveriesTerm singleton gestationsProportional hazards modelSingleton gestationsFetal demiseIndependent predictorsMedical complicationsTerm deliveryWomen 25Women 40Risk factorsMaternal raceCongenital anomaliesPrevention databaseHazards modelHaenszel testWomen 15U.S. CentersCochran-Mantel
2000
Combined ultrasound biometry, serum markers and age for Down syndrome risk estimation
Bahado‐Singh R, Oz A, Gomez K, Hunter D, Copel J, Baumgarten A, Mahoney M. Combined ultrasound biometry, serum markers and age for Down syndrome risk estimation. Ultrasound In Obstetrics And Gynecology 2000, 15: 199-204. PMID: 10846774, DOI: 10.1046/j.1469-0705.2000.00071.x.Peer-Reviewed Original ResearchConceptsMaternal ageAlpha-fetoproteinTriple screenSerum markersUltrasound biometryDown syndromeNuchal thickness measurementMedian maternal ageSerum alpha-fetoproteinNormal singleton pregnanciesHumerus lengthGestational age rangeDown's syndrome screening efficiencySingleton pregnanciesReferral populationFalse positive rateSecond trimesterIndividual Down syndrome oddsFetal biometryUnconjugated estriolStudy groupNuchal thicknessDown syndrome risk estimationHCGAge range
1999
Selective Screening for Gestational Diabetes Mellitus in Adolescent Pregnancies
KHINE M, WINKLESTEIN A, COPEL J. Selective Screening for Gestational Diabetes Mellitus in Adolescent Pregnancies. Obstetrics And Gynecology 1999, 93: 738-742. DOI: 10.1097/00006250-199905000-00020.Peer-Reviewed Original ResearchConceptsGestational diabetes mellitusBody mass indexAdolescent gravidasRisk factorsGestational diabetesRace/ethnicityDiabetes mellitusMass indexHigh prevalenceFamily historyMedical disordersBasis of BMIPrevalence of GDMAdolescent pregnancySelective screeningConclusion Body mass indexGDM risk factorsPrevious obstetric historyImportant risk factorStudent's t-testObstetric historyAdolescent patientsDiseases codesAnomalous fetusesInternational Classification
1998
Elevated amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 in intra-amniotic infection
Hsu C, Meaddough E, Aversa K, Hong S, Lu L, Jones D, Copel J. Elevated amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 in intra-amniotic infection. American Journal Of Obstetrics And Gynecology 1998, 179: 1267-1270. PMID: 9822513, DOI: 10.1016/s0002-9378(98)70144-9.Peer-Reviewed Original ResearchConceptsIntra-amniotic infectionAmniotic fluid levelsLeukemia inhibitory factorInterleukin-6Interleukin-8Fluid levelsInhibitory factorCreatinine levelsPregnant womenPositive amniotic fluid culture resultsAmniotic fluid creatinine levelsElevated amniotic fluid levelsAmniotic fluid culture resultsAmniotic fluid testsEnzyme-linked immunoassayPreterm contractionsPremature rupturePrognostic importanceLeukocyte countSignificant elevationAmniotic fluidMedian levelsCulture resultsInfectionGram stainElevated amniotic fluid nitric oxide metabolites and interleukin-6 in intra-amniotic infection.
Hsu C, Meaddough E, Hong S, Aversa K, Lu L, Copel J. Elevated amniotic fluid nitric oxide metabolites and interleukin-6 in intra-amniotic infection. Reproductive Sciences 1998, 5: 21-4. PMID: 9501294, DOI: 10.1016/s1071-5576(97)00099-3.Peer-Reviewed Original ResearchConceptsAmniotic fluid nitric oxide metabolitesIntra-amniotic infectionNitric oxide metabolitesLeukocyte esterase activityIL-6Oxide metabolitesLeukocyte countInterleukin-6Glucose levelsRank correlation testAmniotic fluid creatinine levelsAmniotic fluid glucose levelAmniotic fluid IL-6Positive amniotic fluid cultureGram stainIL-6 levelsInterleukin-6 concentrationsIL-6 concentrationsAmniotic fluid leukocyte countsUseful clinical markerMann-Whitney U testEnzyme-linked immunosorbentAmniotic fluid cultureCreatinine levelsGestational ageDual Roles of Amniotic Fluid Nitric Oxide and Prostaglandin E2 in Preterm Labor with Intra-Amniotic Infection
Hsu C, Meaddough E, Aversa K, Hong S, Lee I, Bahodo-Singh R, Lu L, Copel J. Dual Roles of Amniotic Fluid Nitric Oxide and Prostaglandin E2 in Preterm Labor with Intra-Amniotic Infection. American Journal Of Perinatology 1998, 15: 683-687. PMID: 10333395, DOI: 10.1055/s-2007-999302.Peer-Reviewed Original ResearchConceptsIntra-amniotic infectionNitric oxide metabolitesPreterm labor patientsAmniotic fluid nitric oxide metabolitesProstaglandin E2Preterm laborLabor patientsNitric oxideIntraamniotic infectionAmniotic fluidAmniotic fluid nitric oxidePositive amniotic fluid cultureAmniotic fluid creatinineProinflammatory nitric oxidePro-inflammatory nitric oxideAmniotic fluid concentrationsAmniotic fluid levelsNitric oxide synthaseCyclo-oxygenase-2Amniotic fluid cultureEnzyme-linked immunoassayOxide metabolitesLeukocyte countFluid cultureOxide synthase
1995
Successful in utero therapy of fetal heart block
Copel J, Buyon J, Kleinman C. Successful in utero therapy of fetal heart block. American Journal Of Obstetrics And Gynecology 1995, 173: 1384-1390. PMID: 7503173, DOI: 10.1016/0002-9378(95)90621-5.Peer-Reviewed Original ResearchConceptsComplete heart blockFetal heart blockHeart blockAntibody levelsCongenital complete heart blockHeart block patientsMaternal antibody levelsPositive antibody screenSimilar antibody levelsSecond-degree blockDegree of blockCardiac conduction systemFetal cardiac conduction systemConcurrent myocarditisGlucocorticoid therapyMaternal autoantibodiesBlock patientsMaternal antibodiesAntibody screenUtero therapyCord samplesCardiac contractilityRapid resolutionB antibodiesCardiac conductionSingle umbilical artery: Does it matter which artery is missing?
Abuhamad A, Shaffer W, Mari G, Copel J, Hobbins J, Evans A. Single umbilical artery: Does it matter which artery is missing? American Journal Of Obstetrics And Gynecology 1995, 173: 728-732. PMID: 7573234, DOI: 10.1016/0002-9378(95)90331-3.Peer-Reviewed Original ResearchConceptsSingle umbilical arteryGestational age fetusesUmbilical arteryLeft arteryCongenital anomaliesRight arteryIsolated single umbilical arteryComplex fetal anomaliesLeft umbilical arteryComplex congenital anomaliesProspective studyIsolated findingFetal anomaliesArteryCytogenetic abnormalitiesComplex anomaliesFetusesPregnancyPrevious reportsAbsenceAbnormalitiesIncidenceSonograms
1985
Hermansky-Pudlak syndrome in pregnancy: Two case studies
Reiss R, Copel J, Roberts N, Hobbins J. Hermansky-Pudlak syndrome in pregnancy: Two case studies. American Journal Of Obstetrics And Gynecology 1985, 153: 564-565. PMID: 4061519, DOI: 10.1016/0002-9378(85)90475-2.Peer-Reviewed Case Reports and Technical Notes