2024
Recurrence patterns and evolution of submicroscopic and asymptomatic Plasmodium vivax infections in malaria-endemic areas of the Peruvian Amazon
Castillo S, Alvarez C, Rosas-Aguirre Á, Acosta C, Corder R, Gómez J, Guzmán M, Speybroeck N, Llanos-Cuentas A, Castro M, Rosanas-Urgell A, Ferreira M, Vinetz J, Gamboa D, Torres K. Recurrence patterns and evolution of submicroscopic and asymptomatic Plasmodium vivax infections in malaria-endemic areas of the Peruvian Amazon. PLOS Neglected Tropical Diseases 2024, 18: e0012566. PMID: 39480785, PMCID: PMC11527163, DOI: 10.1371/journal.pntd.0012566.Peer-Reviewed Original ResearchConceptsRisk of P. vivax infectionPlasmodium vivax malaria transmissionFactors associated with recurrenceVivax malaria transmissionPlasmodium vivax infectionMalaria-endemic areasPopulation-based cohort studyFrequency of recurrenceApplication of molecular diagnostic methodsMalaria recurrenceMalaria infectionMalaria transmissionVivax infectionRecurrence rateMolecular diagnostic methodsRecurrence riskConsequences of prolonged exposureFollow-upCohort studyEndemic settingsRecurrenceAsymptomatic infectionAsymptomatic casesInfectionInitial infectionLower Microscopy Sensitivity with Decreasing Malaria Prevalence in the Urban Amazon Region, Brazil, 2018–2021 - Volume 30, Number 9—September 2024 - Emerging Infectious Diseases journal - CDC
Rodrigues P, Johansen I, Ladeia W, Esquivel F, Corder R, Tonini J, Calil P, Fernandes A, Fontoura P, Cavasini C, Vinetz J, Castro M, Ferreira M, . Lower Microscopy Sensitivity with Decreasing Malaria Prevalence in the Urban Amazon Region, Brazil, 2018–2021 - Volume 30, Number 9—September 2024 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2024, 30: 1884-1894. PMID: 39174028, PMCID: PMC11346994, DOI: 10.3201/eid3009.240378.Peer-Reviewed Original ResearchConceptsEffectiveness of malaria controlDecreasing malaria prevalenceEpidemiology of malariaPoint-of-care microscopyThreshold of microscopyPlasmodium vivaxMalaria prevalenceMalarial infectionMalaria controlMalaria transmissionP. falciparumMicroscopy sensitivityParasite densityAsymptomatic infectionRoutine surveillanceMalariaPrevalence surveyInfectionPrevalenceParasite genotypesTransmission hotspotsElimination strategiesRural residentsMolecular methodsCDCGenomic surveillance of malaria parasites in an indigenous community in the Peruvian Amazon
Cabrera-Sosa L, Nolasco O, Kattenberg J, Fernandez-Miñope C, Valdivia H, Barazorda K, Arévalo de los Rios S, Rodriguez-Ferrucci H, Vinetz J, Rosanas-Urgell A, Van geertruyden J, Gamboa D, Delgado-Ratto C. Genomic surveillance of malaria parasites in an indigenous community in the Peruvian Amazon. Scientific Reports 2024, 14: 16291. PMID: 39009685, PMCID: PMC11250820, DOI: 10.1038/s41598-024-66925-x.Peer-Reviewed Original ResearchConceptsPassive case detectionPf parasitesPersistent malaria transmissionPfhrp2/3 gene deletionsDeep sequencing assaySulfadoxine-pyrimethamineMalaria casesMalaria eliminationPlasmodium vivaxMalaria parasitesMalaria transmissionP. falciparumResistance mutationsImported infectionsMalariaPopulation genetic indicesSequencing assayCase detectionGene deletionPV populationResistance markersGenetic diversityPeruvian AmazonGenomic surveillanceGenetic indices
2022
Effect of out-of-village working activities on recent malaria exposure in the Peruvian Amazon using parametric g-formula
Carrasco-Escobar G, Rosado J, Nolasco O, White M, Mueller I, Castro M, Rodriguez-Ferruci H, Gamboa D, Llanos-Cuentas A, Vinetz J, Benmarhnia T. Effect of out-of-village working activities on recent malaria exposure in the Peruvian Amazon using parametric g-formula. Scientific Reports 2022, 12: 19144. PMID: 36351988, PMCID: PMC9645738, DOI: 10.1038/s41598-022-23528-8.Peer-Reviewed Original ResearchConceptsRecent malaria exposureMalaria exposurePopulation-based cross-sectional studyCommunity-level transmissionMalaria elimination strategiesCross-sectional studyPotential health benefitsWorking activitiesRisk differenceOccupational interventionsMalaria transmissionAdult populationOccupational activitiesHeterogeneous patternUnexposed populationIndividual riskHealth benefitsPopulation subgroupsRural areasElimination strategyVillage workersMean outcomeIntervention scenariosExposurePopulation
2021
Clinical spectrum of endemic leptospirosis in relation to cytokine response
Dahanayaka NJ, Agampodi SB, Seneviratna I, Warnasekara J, Rajapakse R, Ranathunga K, Matthias M, Vinetz JM. Clinical spectrum of endemic leptospirosis in relation to cytokine response. PLOS ONE 2021, 16: e0261025. PMID: 34879100, PMCID: PMC8654203, DOI: 10.1371/journal.pone.0261025.Peer-Reviewed Original ResearchConceptsCytokine responsesLeptospirosis patientsClinical spectrumHigher IL-13 levelsHigher IL-5Acute kidney injuryHigher serum creatinineIL-13 levelsSerum cytokine levelsIL-6 levelsUniversity Teaching HospitalMultiplex cytokine kitKidney injuryLung involvementCytokine levelsSerum creatinineAcute phaseCytokine kitIL-1βAcute samplesConvalescence periodIL-8IL-5Prognostic informationEndemic settingsCohort profile: the Mâncio Lima cohort study of urban malaria in Amazonian Brazil
Johansen IC, Rodrigues PT, Tonini J, Vinetz J, Castro MC, Ferreira MU. Cohort profile: the Mâncio Lima cohort study of urban malaria in Amazonian Brazil. BMJ Open 2021, 11: e048073. PMID: 34789490, PMCID: PMC8727682, DOI: 10.1136/bmjopen-2020-048073.Peer-Reviewed Original ResearchConceptsMalaria transmissionCohort studyPopulation-based open cohort studySARS-CoV-2 IgG antibodiesConsecutive cross-sectional surveysLaboratory-confirmed malariaSustained malaria transmissionOpen cohort studyConsecutive study visitsHigh-risk individualsSimilar study protocolMalaria prevalence ratesCross-sectional surveyMorbidity informationIgG antibodiesStudy protocolStudy visitOverall burdenPrevalence ratesBlood samplesMalaria diagnosisTravel historyControl interventionsStudy participantsGreater riskOptimizing the microscopic agglutination test (MAT) panel for the diagnosis of Leptospirosis in a low resource, hyper-endemic setting with varied microgeographic variation in reactivity
Jayasundara D, Gamage C, Senavirathna I, Warnasekara J, Matthias MA, Vinetz J, Agampodi S. Optimizing the microscopic agglutination test (MAT) panel for the diagnosis of Leptospirosis in a low resource, hyper-endemic setting with varied microgeographic variation in reactivity. PLOS Neglected Tropical Diseases 2021, 15: e0009565. PMID: 34197457, PMCID: PMC8279374, DOI: 10.1371/journal.pntd.0009565.Peer-Reviewed Original ResearchIntegrating Parasitological and Entomological Observations to Understand Malaria Transmission in Riverine Villages in the Peruvian Amazon
Rosas-Aguirre A, Moreno M, Moreno-Gutierrez D, Llanos-Cuentas A, Saavedra M, Contreras-Mancilla J, Barboza J, Alava F, Aguirre K, Carrasco G, Prussing C, Vinetz J, Conn JE, Speybroeck N, Gamboa D. Integrating Parasitological and Entomological Observations to Understand Malaria Transmission in Riverine Villages in the Peruvian Amazon. The Journal Of Infectious Diseases 2021, 223: s99-s110. PMID: 33906225, PMCID: PMC8079135, DOI: 10.1093/infdis/jiaa496.Peer-Reviewed Original ResearchConceptsMalaria prevalenceMalaria transmissionRiverine villagesMalaria risk factorsMalaria transmission dynamicsSubmicroscopic infectionsLocal epidemiologyPolymerase chain reactionIncidence rateRisk factorsHigh prevalenceMalaria casesTreat interventionMalaria strategyPlasmodium vivaxPrevalenceChain reactionTransmission dynamicsAdult AnophelesHigh heterogeneity12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka
Jayasundara D, Senavirathna I, Warnasekara J, Gamage C, Siribaddana S, Kularatne SAM, Matthias M, Mariet JF, Picardeau M, Agampodi S, Vinetz J. 12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka. PLOS Neglected Tropical Diseases 2021, 15: e0009272. PMID: 33735202, PMCID: PMC8009393, DOI: 10.1371/journal.pntd.0009272.Peer-Reviewed Original ResearchConceptsClonal groupsAcute kidney injuryL. interrogansMajor clinical challengeGlobal disease threatsLeptospira speciesL. interrogans infectionKidney injuryLiver impairmentCardiovascular involvementL. borgpeterseniiClinical presentationProspective studyClinical severityClinical challengePathogenic Leptospira speciesAnnual epidemicsUbiquitous zoonotic diseaseNew serogroupEpidemiological contextZoonotic diseaseCulture isolationLeptospiral culturesL. weiliiLeptospira diversity
2018
Acceptability of a herd immunity-focused, transmission-blocking malaria vaccine in malaria-endemic communities in the Peruvian Amazon: an exploratory study
White SE, Harvey SA, Meza G, Llanos A, Guzman M, Gamboa D, Vinetz JM. Acceptability of a herd immunity-focused, transmission-blocking malaria vaccine in malaria-endemic communities in the Peruvian Amazon: an exploratory study. Malaria Journal 2018, 17: 179. PMID: 29703192, PMCID: PMC5921293, DOI: 10.1186/s12936-018-2328-z.Peer-Reviewed Original ResearchConceptsTransmission-blocking malaria vaccineTransmission-blocking vaccinesMalaria vaccineMalaria transmission-blocking vaccineMalaria hypoendemic regionMalaria vaccine strategyProspective cohort studyMalaria-endemic communitiesMalaria-endemic regionsPre-validated questionnaireCohort studyVaccine strategiesMalaria infectionMethodsThe studyVaccineMalaria controlMalaria researchMultiple injectionsOne-thirdIndustrialized worldInjectionAcceptabilityCohortInfectionStudy
2016
Reactive Case Detection for Plasmodium vivax Malaria Elimination in Rural Amazonia
Fontoura PS, Finco BF, Lima NF, de Carvalho JF, Vinetz JM, Castro MC, Ferreira MU. Reactive Case Detection for Plasmodium vivax Malaria Elimination in Rural Amazonia. PLOS Neglected Tropical Diseases 2016, 10: e0005221. PMID: 27941968, PMCID: PMC5179126, DOI: 10.1371/journal.pntd.0005221.Peer-Reviewed Original ResearchConceptsMalaria eliminationIndex caseElimination effortsControl householdsCorrelates of infectionReactive case detectionMixed-effects logistic regression modelResidual malaria transmissionCase detection strategiesMolecular genotypingMalaria elimination effortsP. vivax transmissionTotal parasite biomassReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionLogistic regression modelsP. vivax diversityPotential confoundersAsymptomatic carriersPolymerase chain reactionCase detectionIndex householdsQPCR-positive samplesMalaria burdenPlasmodium vivax
2005
Clinical Spectrum of Pulmonary Involvement in Leptospirosis in a Region of Endemicity, with Quantification of Leptospiral Burden
Segura ER, Ganoza CA, Campos K, Ricaldi JN, Torres S, Silva H, Céspedes MJ, Matthias MA, Swancutt MA, Liñán R, Gotuzzo E, Guerra H, Gilman RH, Vinetz JM, Consortium P. Clinical Spectrum of Pulmonary Involvement in Leptospirosis in a Region of Endemicity, with Quantification of Leptospiral Burden. Clinical Infectious Diseases 2005, 40: 343-351. PMID: 15668855, PMCID: PMC2366057, DOI: 10.1086/427110.Peer-Reviewed Original ResearchConceptsPulmonary involvementFebrile patientsAcute respiratory distress syndromeMost fatal casesSevere pulmonary manifestationsRespiratory distress syndromePopulation-based studyEvidence of exposureDiagnosis of leptospirosisRegions of endemicityPulmonary complicationsMultiorgan failurePulmonary manifestationsPresumptive treatmentDistress syndromePulmonary hemorrhageSerologic testingIgM antibodiesClinical spectrumPulmonary casesFatal casesQuantitative real-time PCRReal-time PCRAntileptospiral antibodiesLeptospiral burden
2001
Erythrocytapheresis for Plasmodium falciparum infection complicated by cerebral malaria and hyperparasitemia
Zhang Y, Telleria L, Vinetz J, Yawn D, Rossmann S, Indrikovs A. Erythrocytapheresis for Plasmodium falciparum infection complicated by cerebral malaria and hyperparasitemia. Journal Of Clinical Apheresis 2001, 16: 15-18. PMID: 11309825, DOI: 10.1002/jca.1002.Peer-Reviewed Original ResearchConceptsRed blood cell exchangeCell exchangeAnti-malarial chemotherapyWhole blood exchangeEnd-organ dysfunctionLife-threatening complicationsPlasmodium falciparum infectionRed cell exchangeCirculation of patientsDegree of parasitemiaComplicated malariaCerebral malariaRenal dysfunctionFalciparum infectionHigher parasite loadsBlood exchangePatientsP. falciparumFull recoveryPlasmodium falciparumMalariaParasite loadHyperparasitemiaChemotherapyParasitemia