Featured Publications
Malaria Resilience in South America: Epidemiology, Vector Biology, and Immunology Insights from the Amazonian International Center of Excellence in Malaria Research Network in Peru and Brazil
Torres K, Ferreira MU, Castro MC, Escalante AA, Conn JE, Villasis E, da Silva Araujo M, Almeida G, Rodrigues PT, Corder RM, Fernandes ARJ, Calil PR, Ladeia WA, Garcia-Castillo SS, Gomez J, do Valle Antonelli LR, Gazzinelli RT, Golenbock DT, Llanos-Cuentas A, Gamboa D, Vinetz JM. Malaria Resilience in South America: Epidemiology, Vector Biology, and Immunology Insights from the Amazonian International Center of Excellence in Malaria Research Network in Peru and Brazil. American Journal Of Tropical Medicine And Hygiene 2022, 107: 168-181. PMID: 36228921, PMCID: PMC9662219, DOI: 10.4269/ajtmh.22-0127.Peer-Reviewed Original ResearchConceptsImmune responseMalaria epidemiologyMalaria controlImportant public health priorityHuman immune responsePublic health priorityWestern Brazilian Amazon regionHealth priorityHuman reservoirSociodemographic featuresMalaria researchEpidemiologyMultidisciplinary approachRapid reemergenceVector biologyElimination strategyResearch NetworkMalaria vectorsInternational CentreFurther researchBrazilian Amazon regionSouth AmericaMalariaImmunologyResponse
2024
Lower Microscopy Sensitivity with Decreasing Malaria Prevalence in the Urban Amazon Region, Brazil, 2018–2021 - Volume 30, Number 9—September 2024 - Emerging Infectious Diseases journal - CDC
Rodrigues P, Johansen I, Ladeia W, Esquivel F, Corder R, Tonini J, Calil P, Fernandes A, Fontoura P, Cavasini C, Vinetz J, Castro M, Ferreira M, . Lower Microscopy Sensitivity with Decreasing Malaria Prevalence in the Urban Amazon Region, Brazil, 2018–2021 - Volume 30, Number 9—September 2024 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2024, 30: 1884-1894. PMID: 39174028, PMCID: PMC11346994, DOI: 10.3201/eid3009.240378.Peer-Reviewed Original ResearchConceptsEffectiveness of malaria controlDecreasing malaria prevalenceEpidemiology of malariaPoint-of-care microscopyThreshold of microscopyPlasmodium vivaxMalaria prevalenceMalarial infectionMalaria controlMalaria transmissionP. falciparumMicroscopy sensitivityParasite densityAsymptomatic infectionRoutine surveillanceMalariaPrevalence surveyInfectionPrevalenceParasite genotypesTransmission hotspotsElimination strategiesRural residentsMolecular methodsCDC
2023
Mutations Linked to Insecticide Resistance Not Detected in the Ace-1 or VGSC Genes in Nyssorhynchus darlingi from Multiple Localities in Amazonian Brazil and Peru
Bickersmith S, Jurczynski J, Sallum M, Chaves L, Bergo E, Rodriguez G, Morante C, Rios C, Saavedra M, Alava F, Gamboa D, Vinetz J, Conn J. Mutations Linked to Insecticide Resistance Not Detected in the Ace-1 or VGSC Genes in Nyssorhynchus darlingi from Multiple Localities in Amazonian Brazil and Peru. Genes 2023, 14: 1892. PMID: 37895241, PMCID: PMC10606710, DOI: 10.3390/genes14101892.Peer-Reviewed Original ResearchConceptsIndoor residual sprayMalaria endemic localitiesLow-intensity resistanceResistance mechanismsMalaria hotspotsCommon interventionInsecticidal netsMain resistance mechanismMalaria transmissionGenotypic detectionCodon 280Resistance mutationsEndemic localitiesPrimary malaria vectorVoltage-gated sodium channel geneResidual spraySodium channel geneChannel genesNon-synonymous mutationsACEPresent studyMalaria vectorsInterventionMutationsS6 segment
2022
Evidence-Based Malaria Control and Elimination in the Amazon: Input from the International Center of Excellence in Malaria Research Network in Peru and Brazil
Ferreira MU, Gamboa D, Torres K, Rodriguez-Ferrucci H, Soto-Calle VE, Pardo K, Fontoura PS, Tomko SS, Gazzinelli RT, Conn JE, Castro MC, Llanos-Cuentas A, Vinetz JM. Evidence-Based Malaria Control and Elimination in the Amazon: Input from the International Center of Excellence in Malaria Research Network in Peru and Brazil. American Journal Of Tropical Medicine And Hygiene 2022, 107: 160-167. PMID: 36228907, PMCID: PMC9662230, DOI: 10.4269/ajtmh.21-1272.Peer-Reviewed Original ResearchConceptsMalaria controlAsymptomatic Plasmodium infectionsPredominant malaria parasitePublic health decision makersMalaria control strategiesPublic health implicationsIndoor residual sprayingBetter malaria controlHealth decision makersVector control measuresPlasmodium infectionInfectious reservoirMalaria burdenPlasmodium vivaxBed netsPublic health policymakingElimination programMalaria parasitesResidual sprayingMalaria researchHealth implicationsNyssorhynchus darlingiDiagnostic methodsHealth policymakingResearch Network
2021
Cohort profile: the Mâncio Lima cohort study of urban malaria in Amazonian Brazil
Johansen IC, Rodrigues PT, Tonini J, Vinetz J, Castro MC, Ferreira MU. Cohort profile: the Mâncio Lima cohort study of urban malaria in Amazonian Brazil. BMJ Open 2021, 11: e048073. PMID: 34789490, PMCID: PMC8727682, DOI: 10.1136/bmjopen-2020-048073.Peer-Reviewed Original ResearchConceptsMalaria transmissionCohort studyPopulation-based open cohort studySARS-CoV-2 IgG antibodiesConsecutive cross-sectional surveysLaboratory-confirmed malariaSustained malaria transmissionOpen cohort studyConsecutive study visitsHigh-risk individualsSimilar study protocolMalaria prevalence ratesCross-sectional surveyMorbidity informationIgG antibodiesStudy protocolStudy visitOverall burdenPrevalence ratesBlood samplesMalaria diagnosisTravel historyControl interventionsStudy participantsGreater riskAsymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi
Almeida GG, Costa PAC, da Silva Araujo M, Gomes GR, Carvalho AF, Figueiredo MM, Pereira DB, Tada MS, Medeiros JF, da Silva Soares I, Carvalho LH, Kano FS, de Castro M, Vinetz JM, Golenbock DT, do Valle Antonelli L, Gazzinelli RT. Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi. PLOS Neglected Tropical Diseases 2021, 15: e0009077. PMID: 34714821, PMCID: PMC8555776, DOI: 10.1371/journal.pntd.0009077.Peer-Reviewed Original ResearchConceptsAsymptomatic individualsP. vivaxP. vivax malaria patientsP. vivax infectionVivax malaria patientsPlasmodium vivax malariaLow endemicity areaMalaria patientsSymptomatic patientsAsymptomatic infectionVivax malariaVivax infectionInfectious reservoirLow parasitemiaUninfected controlsEndemic regionsMalaria transmissionInfectivity ratesMalaria parasitesBiochemical parametersParasitemiaBloodPotential rolePatientsInfectionEcology and larval population dynamics of the primary malaria vector Nyssorhynchus darlingi in a high transmission setting dominated by fish farming in western Amazonian Brazil
Rufalco-Moutinho P, Kadri S, Alonso D, Moreno M, Carrasco-Escobar G, Prussing C, Gamboa D, Vinetz JM, Sallum M, Conn JE, Ribolla P. Ecology and larval population dynamics of the primary malaria vector Nyssorhynchus darlingi in a high transmission setting dominated by fish farming in western Amazonian Brazil. PLOS ONE 2021, 16: e0246215. PMID: 33831004, PMCID: PMC8031405, DOI: 10.1371/journal.pone.0246215.Peer-Reviewed Original ResearchConceptsHigh transmission settingsHigh human densityHuman biting rateMalaria transmission hotspotsWestern Amazonian BrazilLocal malaria burdenLarval population dynamicsAquatic vegetationLandscape typesHuman densitySame sampling periodMalaria burdenRural landscapesTransmission settingsDarlingi larvaeWestern AcrePopulation maintenanceUrban landscapeAdult samplingMain malaria vectorBreeding sitesLandscape profileDry seasonMalaria vector speciesPopulation dynamicsHeterogeneity in response to serological exposure markers of recent Plasmodium vivax infections in contrasting epidemiological contexts
Rosado J, White MT, Longley RJ, Lacerda M, Monteiro W, Brewster J, Sattabongkot J, Guzman-Guzman M, Llanos-Cuentas A, Vinetz JM, Gamboa D, Mueller I. Heterogeneity in response to serological exposure markers of recent Plasmodium vivax infections in contrasting epidemiological contexts. PLOS Neglected Tropical Diseases 2021, 15: e0009165. PMID: 33591976, PMCID: PMC7909627, DOI: 10.1371/journal.pntd.0009165.Peer-Reviewed Original ResearchConceptsSerological exposure markersBlood-stage infectionLow transmission settingsP. vivax infectionPlasmodium vivax infectionHigh transmission settingsVivax infectionTransmission settingsAntibody titersAntibody responseExposure markersDifferent transmission intensitiesIgG responsesSerological markersPrevious infectionReceiver Operating Characteristic (ROC) analysisEndemic settingsMalaria eliminationPeruvian cohortOperating characteristics analysisP. vivaxMalaria controlRecent exposureInfectionEpidemiological context
2016
Reactive Case Detection for Plasmodium vivax Malaria Elimination in Rural Amazonia
Fontoura PS, Finco BF, Lima NF, de Carvalho JF, Vinetz JM, Castro MC, Ferreira MU. Reactive Case Detection for Plasmodium vivax Malaria Elimination in Rural Amazonia. PLOS Neglected Tropical Diseases 2016, 10: e0005221. PMID: 27941968, PMCID: PMC5179126, DOI: 10.1371/journal.pntd.0005221.Peer-Reviewed Original ResearchConceptsMalaria eliminationIndex caseElimination effortsControl householdsCorrelates of infectionReactive case detectionMixed-effects logistic regression modelResidual malaria transmissionCase detection strategiesMolecular genotypingMalaria elimination effortsP. vivax transmissionTotal parasite biomassReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionLogistic regression modelsP. vivax diversityPotential confoundersAsymptomatic carriersPolymerase chain reactionCase detectionIndex householdsQPCR-positive samplesMalaria burdenPlasmodium vivax