2019
Prestin kinetics and corresponding frequency dependence augment during early development of the outer hair cell within the mouse organ of Corti
Bai JP, Navaratnam D, Santos-Sacchi J. Prestin kinetics and corresponding frequency dependence augment during early development of the outer hair cell within the mouse organ of Corti. Scientific Reports 2019, 9: 16460. PMID: 31712635, PMCID: PMC6848539, DOI: 10.1038/s41598-019-52965-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAuditory PathwaysElectric CapacitanceGene Expression Regulation, DevelopmentalHair Cells, Auditory, OuterHearingKineticsMechanotransduction, CellularMiceMice, Inbred C57BLMolecular Motor ProteinsOrgan of CortiConceptsOuter hair cellsPostnatal dayVoltage-sensor charge movementAltricial animalsPostnatal developmentCochlear placeElectrical correlatesHair cellsMouse organsCochlear amplificationEarly developmentAuditory frequencyPrestin activityAuditory capabilitiesCellsCharge movementHigh frequencyResponse increasesPrestin functionMiceActivityMonthsCourse
2011
Gene Expression Gradients along the Tonotopic Axis of the Chicken Auditory Epithelium
Frucht CS, Uduman M, Kleinstein SH, Santos-Sacchi J, Navaratnam DS. Gene Expression Gradients along the Tonotopic Axis of the Chicken Auditory Epithelium. Journal Of The Association For Research In Otolaryngology 2011, 12: 423-435. PMID: 21399991, PMCID: PMC3123449, DOI: 10.1007/s10162-011-0259-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCalcium ChannelsChickensCyclic AMP-Dependent Protein KinasesGene Expression ProfilingGene Expression Regulation, DevelopmentalHair Cells, AuditoryLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsMicroRNAsModels, AnimalOrgan of CortiProtein Kinase CSodium ChannelsConceptsGene expression gradientsAuditory epitheliumKinases protein kinase CChicken auditory epitheliumExpression gradientsAvian auditory epitheliumBasilar papillaFold-change cutoffActivity of kinasesIon channel genesProtein kinase CChicken basilar papillaGene setsGenetic basisEnrichment analysisExpression patternsGene expressionGeneSpring softwareChannel genesMechanism of inductionKinase CGenesMicroarray dataDifferential activityQuantitative PCR
2007
Developmental Expression of the Outer Hair Cell Motor Prestin in the Mouse
Abe T, Kakehata S, Kitani R, Maruya S, Navaratnam D, Santos-Sacchi J, Shinkawa H. Developmental Expression of the Outer Hair Cell Motor Prestin in the Mouse. The Journal Of Membrane Biology 2007, 215: 49-56. PMID: 17415610, PMCID: PMC4154540, DOI: 10.1007/s00232-007-9004-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGene Expression Regulation, DevelopmentalHair Cells, Auditory, OuterMiceMice, Inbred C57BLMolecular Motor ProteinsProtein ConformationProteinsConceptsLateral membranesOuter hair cellsMouse outer hair cellsMotor protein activitySteady-state levelsKnockout experimentsProtein activityDevelopmental expressionMembrane tensionGenetic modificationConformational fluctuationsCellular mechanismsMotor moleculesMolecular motorsOnset of hearingMorphological estimatesProtein densityEarly maturationQuantitative polymerase chain reactionHair cellsVpkCmDevelopmental dataCochlear amplificationMaturationFull maturation