2010
The remarkable cochlear amplifier
Ashmore J, Avan P, Brownell W, Dallos P, Dierkes K, Fettiplace R, Grosh K, Hackney C, Hudspeth A, Jülicher F, Lindner B, Martin P, Meaud J, Petit C, Santos-Sacchi J, Sacchi J, Canlon B. The remarkable cochlear amplifier. Hearing Research 2010, 266: 1-17. PMID: 20541061, PMCID: PMC6366996, DOI: 10.1016/j.heares.2010.05.001.Peer-Reviewed Original Research
2001
Non-uniform mapping of stress-induced, motility-related charge movement in the outer hair cell plasma membrane
Takahashi S, Santos-Sacchi J. Non-uniform mapping of stress-induced, motility-related charge movement in the outer hair cell plasma membrane. Pflügers Archiv - European Journal Of Physiology 2001, 441: 506-513. PMID: 11212214, DOI: 10.1007/s004240000455.Peer-Reviewed Original ResearchConceptsCell plasma membranePlasma membraneLateral membranesOuter hair cell plasma membraneVoltage-dependent motilityMammalian cochlear amplifierOuter hair cell electromotilityMembrane microdomainsGating currentsHair cell electromotilityTurgor pressureOHC motorMolecular motorsElectromotile responseMembraneMotilityCytoskeletonCharge movementBell-shaped distributionMicrodomainsElectromotilityNon-uniform mappingPronase treatmentCochlear amplifierPronase
1998
Effect of Membrane Tension on Gap Junctional Conductance of Supporting Cells in Corti's Organ
Zhao H, Santos-Sacchi J. Effect of Membrane Tension on Gap Junctional Conductance of Supporting Cells in Corti's Organ. The Journal Of General Physiology 1998, 112: 447-455. PMID: 9758863, PMCID: PMC2229429, DOI: 10.1085/jgp.112.4.447.Peer-Reviewed Original ResearchConceptsTurgor pressureInner ear gap junctionsMembrane tensionPositive turgor pressureProtein kinase inhibitorsGap junctionsOsmotic pressure regulationPipette pressureSupporting cellsInner earMicroM HCochlear homeostasisGap junctional conductanceKinase inhibitorsMechanical forcesCell sizeJunctional conductance
1996
Effects of Salicylate and Lanthanides on Outer Hair Cell Motility and Associated Gating Charge
Kakehata S, Santos-Sacchi J. Effects of Salicylate and Lanthanides on Outer Hair Cell Motility and Associated Gating Charge. Journal Of Neuroscience 1996, 16: 4881-4889. PMID: 8756420, PMCID: PMC6579298, DOI: 10.1523/jneurosci.16-16-04881.1996.Peer-Reviewed Original ResearchConceptsOuter hair cellsEffects of salicylateConcentration-response curvesGuinea pig outer hair cellsOHC motilityAuditory frequency selectivityForm of salicylateHalf-maximal concentrationReversible tinnitusHearing lossDepolarized levelsHair cell motilityComparable groupsHair cellsOuter Hair Cell MotilityInner aspectOuter aspectSubsurface cisternaeTrypsin treatmentMotilityPressure changesHill coefficientSalicylatePresent experimentsVoltage-induced movement