2021
Comprehensive somatosensory and neurological phenotyping of NCS1 knockout mice
Nguyen LD, Nolte LG, Tan WJT, Giuvelis D, Santos-Sacchi J, Bilsky E, Ehrlich BE. Comprehensive somatosensory and neurological phenotyping of NCS1 knockout mice. Scientific Reports 2021, 11: 2372. PMID: 33504822, PMCID: PMC7840744, DOI: 10.1038/s41598-021-81650-5.Peer-Reviewed Original ResearchConceptsNeuronal calcium sensor-1Peripheral nervous systemNervous systemMale miceKnockout micePaclitaxel-induced peripheral neuropathyKO modelKO male miceNCS1 expressionMammalian nervous systemPrecise physiological significanceSex-specific effectsPeripheral neuropathyFemale miceModulatory roleBehavioral testsPharmacological targetsMiceNeurodegenerative diseasesClinical interestMemory acquisitionMotor performancePathological statesAffective behaviorDisease
2001
Non-uniform mapping of stress-induced, motility-related charge movement in the outer hair cell plasma membrane
Takahashi S, Santos-Sacchi J. Non-uniform mapping of stress-induced, motility-related charge movement in the outer hair cell plasma membrane. Pflügers Archiv - European Journal Of Physiology 2001, 441: 506-513. PMID: 11212214, DOI: 10.1007/s004240000455.Peer-Reviewed Original ResearchConceptsCell plasma membranePlasma membraneLateral membranesOuter hair cell plasma membraneVoltage-dependent motilityMammalian cochlear amplifierOuter hair cell electromotilityMembrane microdomainsGating currentsHair cell electromotilityTurgor pressureOHC motorMolecular motorsElectromotile responseMembraneMotilityCytoskeletonCharge movementBell-shaped distributionMicrodomainsElectromotilityNon-uniform mappingPronase treatmentCochlear amplifierPronase