A phase I trial of naloxone treatment in acute spinal cord injury.
Flamm E, Young W, Collins W, Piepmeier J, Clifton G, Fischer B. A phase I trial of naloxone treatment in acute spinal cord injury. Journal Of Neurosurgery 1985, 63: 390-7. PMID: 3894597, DOI: 10.3171/jns.1985.63.3.0390.Peer-Reviewed Original ResearchConceptsGroup 2 patientsSpinal cord injuryAcute spinal cord injuryPhase I trialTime of admissionLoading doseCord injuryMaintenance doseI trialExperimental spinal cord injuryComplete neurological deficitGroup 1 patientsWeeks of admissionDose-related fashionTreatment of patientsOpiate antagonist naloxoneIncomplete deficitsMaintenance infusionNeurological deficitsNeurological statusNaloxone treatmentNeurological examinationAntagonist naloxoneInitial doseContinuous infusion