Targeting microtubule-associated proteins in glioblastoma: A new strategy for selective therapy
Piepmeier J, Pedersen P, Yoshida D, Greer C. Targeting microtubule-associated proteins in glioblastoma: A new strategy for selective therapy. Annals Of Surgical Oncology 1996, 3: 543-549. PMID: 8915486, DOI: 10.1007/bf02306087.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic Agents, AlkylatingBrain NeoplasmsCarrier ProteinsCell LineColony-Forming Units AssayEstramustineFlow CytometryGlioblastomaHumansImmunohistochemistryMiceMice, NudeMicrotubule-Associated ProteinsNeoplasm TransplantationRadiation-Sensitizing AgentsThymidineTransplantation, HeterologousTumor Cells, CulturedConceptsSubcutaneous xenograftsGlioblastoma cellsHuman glioblastoma cellsMicrotubule-associated proteinsHuman glioblastomaPotent antimitotic effectsUse of estramustineAntimicrotubule agentsEstramustine-binding proteinPreclinical dataEstramustineNeoplastic cellsAntiproliferative effectsSelective therapyGlioma cellsAntimitotic effectCytotoxic effectsGlioblastomaUseful targetTherapyXenograftsLaboratory investigationsSelective effectAntimitotic activityCellsIn vitro and in vivo inhibition of glioblastoma and neuroblastoma with MDL101731, a novel ribonucleoside diphosphate reductase inhibitor.
Piepmeier J, Rabidou N, Schold S, Bitonti A, Prakash N, Bush T. In vitro and in vivo inhibition of glioblastoma and neuroblastoma with MDL101731, a novel ribonucleoside diphosphate reductase inhibitor. Cancer Research 1996, 56: 359-61. PMID: 8542592.Peer-Reviewed Original ResearchConceptsMalignant brain tumorsMedian survivalControl animalsAthymic miceBrain tumorsReductase inhibitorsHuman malignant brain tumorsHuman glioblastomaDays of treatmentSK-N-MCConcentration-dependent inhibitionTumor regressionIntracerebral implantsIntracerebral xenograftsXenograft modelGlioblastoma cell linesVivo inhibitionPotent antiproliferative activityNeuroblastomaGlioblastomaSurvivalCell linesXenograftsNanomolar concentrationsTumors