2015
ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy
Albright RA, Stabach P, Cao W, Kavanagh D, Mullen I, Braddock AA, Covo MS, Tehan M, Yang G, Cheng Z, Bouchard K, Yu ZX, Thorn S, Wang X, Folta-Stogniew EJ, Negrete A, Sinusas AJ, Shiloach J, Zubal G, Madri JA, De La Cruz EM, Braddock DT. ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy. Nature Communications 2015, 6: 10006. PMID: 26624227, PMCID: PMC4686714, DOI: 10.1038/ncomms10006.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseVascular calcificationArterial calcificationOrphan diseaseCommon diseaseSequelae of diseaseEctopic vascular calcificationInternal elastic laminaPrevent mortalityRenal failureCardiac failureKidney diseaseSubcutaneous administrationRodent modelsAnimal modelsEctopic calcificationVascular wallLarge arteriesElastic laminaDiseaseCalcificationCalciphylaxisDecreased concentrationSclerosisArtery
2006
γδ T Cells Facilitate Adaptive Immunity against West Nile Virus Infection in Mice
Wang T, Gao Y, Scully E, Davis CT, Anderson JF, Welte T, Ledizet M, Koski R, Madri JA, Barrett A, Yin Z, Craft J, Fikrig E. γδ T Cells Facilitate Adaptive Immunity against West Nile Virus Infection in Mice. The Journal Of Immunology 2006, 177: 1825-1832. PMID: 16849493, DOI: 10.4049/jimmunol.177.3.1825.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsCD8-Positive T-LymphocytesGenetic Predisposition to DiseaseImmunity, CellularImmunity, InnateImmunization, SecondaryImmunoglobulin GImmunoglobulin MImmunologic MemoryLymphocyte DepletionMiceMice, Inbred C57BLMice, KnockoutReceptors, Antigen, T-Cell, gamma-deltaRecurrenceT-Lymphocyte SubsetsWest Nile FeverWest Nile virusConceptsGammadelta T cellsWild-type miceT cellsWN virus infectionPrimary infectionVirus infectionWN virusNaive miceSecondary challengeImmune responseAdaptive immunityCD8 memory T cellsWest Nile virus infectionMemory T cellsProtective immune responseAdaptive immune responsesAdoptive transferWest Nile virusAb responsesLethal infectionViral challengeFatal meningoencephalitisSecondary infectionInfectionMice
1989
MHC control of CD4+ T cell subset activation.
Murray J, Madri J, Tite J, Carding S, Bottomly K. MHC control of CD4+ T cell subset activation. Journal Of Experimental Medicine 1989, 170: 2135-2140. PMID: 2573684, PMCID: PMC2189542, DOI: 10.1084/jem.170.6.2135.Peer-Reviewed Original ResearchConceptsT cellsIL-2IL-4-producing CD4T cell subset activationIL-4-producing cellsI-Ab miceMHC class II haplotypesCytokine-producing CD4T-cell phenotypeTypes of CD4Secondary IgG responsesClass II MHCSelective activationClass II haplotypesMHC controlSuch selective activationCytokine phenotypeIgG responsesSubset activationII MHCImmune responseProliferative responseCD4Vivo responseMice
1983
A Monoclonal Antibody Specific for the Amino Terminal Cleavage Site of Procollagen Type I
FOELLMER H, KAWAHARA K, MADRI J, FURTHMAYR H, TIMPL R, TUDERMAN L. A Monoclonal Antibody Specific for the Amino Terminal Cleavage Site of Procollagen Type I. The FEBS Journal 1983, 134: 183-189. PMID: 6190652, DOI: 10.1111/j.1432-1033.1983.tb07549.x.Peer-Reviewed Original Research