2000
Neuronal VEGF expression correlates with angiogenesis in postnatal developing rat brain
Ogunshola O, Stewart W, Mihalcik V, Solli T, Madri J, Ment L. Neuronal VEGF expression correlates with angiogenesis in postnatal developing rat brain. Brain Research 2000, 119: 139-153. PMID: 10648880, DOI: 10.1016/s0165-3806(99)00125-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCell CountCerebral CortexChronic DiseaseEndothelial Growth FactorsGene Expression Regulation, DevelopmentalGlial Fibrillary Acidic ProteinHypoxia, BrainLymphokinesMicrocirculationNeovascularization, PhysiologicNeurogliaNeuronsPlatelet Endothelial Cell Adhesion Molecule-1RatsRNA, MessengerVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsVascular endothelial growth factorLocalization of VEGFCortical neuronsGlial cellsNeuronal expressionChronic sublethal hypoxiaRat brain cortexAge-matched controlsCortical brain tissueHypoxia-driven angiogenesisPostnatal day 3Endothelial growth factorDensity of vesselsWestern blot analysisHypoxic animalsHypoxic chamberVascular bedNewborn ratsRat brainBrain cortexControl animalsDay 3High neuronal expressionSublethal hypoxiaPostnatal development
1997
Vascular endothelial growth factor mediates reactive angiogenesis in the postnatal developing brain
Ment L, Stewart W, Fronc R, Seashore C, Mahooti S, Scaramuzzino D, Madri J. Vascular endothelial growth factor mediates reactive angiogenesis in the postnatal developing brain. Brain Research 1997, 100: 52-61. PMID: 9174246, DOI: 10.1016/s0165-3806(97)00012-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAstrocytesCell DivisionCell HypoxiaCells, CulturedCerebral CortexCoculture TechniquesEndothelial Growth FactorsEndothelium, VascularHypoxia, BrainLymphokinesMicrocirculationNeovascularization, PathologicNeovascularization, PhysiologicRatsRats, Sprague-DawleyRNA, MessengerTranscription, GeneticVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsVascular endothelial growth factorEndothelial growth factorVEGF protein levelsExperimental ratsSublethal hypoxiaBrain microvascular endothelial cellsEndothelial cellsGrowth factorChronic sublethal hypoxiaProtein levelsAge-matched controlsMicrovascular endothelial cellsHypoxic pupsHRP studyCortical vesselsImmunohistochemical studyVascular densityAddition of VEGFBeagle pupsNewborn ratsReactive angiogenesisAstrocyte culturesThree-dimensional cocultureRat forebrainVEGF protein