2000
Matrix metalloproteinase activity is required for activity-induced angiogenesis in rat skeletal muscle
Haas T, Milkiewicz M, Davis S, Zhou A, Egginton S, Brown M, Madri J, Hudlicka O. Matrix metalloproteinase activity is required for activity-induced angiogenesis in rat skeletal muscle. AJP Heart And Circulatory Physiology 2000, 279: h1540-h1547. PMID: 11009439, DOI: 10.1152/ajpheart.2000.279.4.h1540.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCapillariesCell DivisionDipeptidesElectric StimulationImmunohistochemistryMatrix Metalloproteinase 2Matrix Metalloproteinase InhibitorsMatrix Metalloproteinases, Membrane-AssociatedMetalloendopeptidasesMicroscopy, ElectronMotor ActivityMuscle, SkeletalNeovascularization, PhysiologicProtease InhibitorsRatsRNA, MessengerConceptsMembrane proteinsBasement membrane proteinsEndothelial cell sprout formationRat skeletal muscleSkeletal muscleMatrix metalloproteinasesMembrane type 1Inflammation-mediated angiogenesisPhysiological angiogenesisBasement membraneCell proliferationMMP proteolysisProtein levelsProteolysisSprout formationMajor classesCritical roleProteinMatrix metalloproteinase activityMetalloproteinase activityProliferationAngiogenesisNew capillariesMembraneMMP inhibition
1999
Egr-1 Mediates Extracellular Matrix-driven Transcription of Membrane Type 1 Matrix Metalloproteinase in Endothelium*
Haas T, Stitelman D, Davis S, Apte S, Madri J. Egr-1 Mediates Extracellular Matrix-driven Transcription of Membrane Type 1 Matrix Metalloproteinase in Endothelium*. Journal Of Biological Chemistry 1999, 274: 22679-22685. PMID: 10428849, DOI: 10.1074/jbc.274.32.22679.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCloning, MolecularDNA-Binding ProteinsEarly Growth Response Protein 1Endothelium, VascularExtracellular MatrixGene Expression Regulation, EnzymologicHalf-LifeImmediate-Early ProteinsMatrix Metalloproteinase 14Matrix Metalloproteinases, Membrane-AssociatedMetalloendopeptidasesMiceMolecular Sequence DataNeovascularization, PhysiologicProtein BindingRatsRNA, MessengerSp1 Transcription FactorTranscription FactorsTranscription, GeneticUp-RegulationConceptsMembrane type 1 matrix metalloproteinaseEgr-1MT1-MMPTranscription factor Egr-1Number of proteinsExtracellular matrix environmentEnhanced transcriptional activityEndothelial cellsTranscriptional activityPromoter correlatesIncreased transcriptionCellular invasionInvasive phenotypeMatrix metalloproteinaseTranscriptionMatrix environmentMatrix metalloproteinase activityMetalloproteinase activityCellsMatrix metalloproteinasesInvasionIncrease productionAngiogenesisMetalloproteinaseProtein