2022
Influence of tumor mutational burden, inflammatory gene expression profile, and PD-L1 expression on response to pembrolizumab in head and neck squamous cell carcinoma
Haddad RI, Seiwert TY, Chow LQM, Gupta S, Weiss J, Gluck I, Eder JP, Burtness B, Tahara M, Keam B, Kang H, Muro K, Albright A, Mogg R, Ayers M, Huang L, Lunceford J, Cristescu R, Cheng J, Mehra R. Influence of tumor mutational burden, inflammatory gene expression profile, and PD-L1 expression on response to pembrolizumab in head and neck squamous cell carcinoma. Journal For ImmunoTherapy Of Cancer 2022, 10: e003026. PMID: 35217573, PMCID: PMC8883256, DOI: 10.1136/jitc-2021-003026.Peer-Reviewed Original ResearchConceptsNeck squamous cell carcinomaSquamous cell carcinomaPD-L1P16 immunohistochemistryCell carcinomaAnti-programmed death-1 therapyRecurrent/metastatic headInflammatory gene expression profileTumor human papillomavirus (HPV) statusPD-L1 CPSHuman papillomavirus (HPV) statusPD-L1 expressionRandomized clinical trialsTumor mutational burdenPretreatment tumor samplesWhole-exome sequencingM HNSCCMetastatic headClinical responseHPV resultsHPV statusInflammatory biomarkersObjective responseClinical outcomesClinical trials
2021
Clinical Efficacy of Olaparib in IDH1/IDH2-Mutant Mesenchymal Sarcomas
Eder JP, Doroshow DB, T. K, Keedy VL, Sklar JS, Glazer P, Bindra R, Shapiro GI. Clinical Efficacy of Olaparib in IDH1/IDH2-Mutant Mesenchymal Sarcomas. JCO Precision Oncology 2021, 5: 466-472. PMID: 34994649, PMCID: PMC9848565, DOI: 10.1200/po.20.00247.Peer-Reviewed Original ResearchConceptsPulmonary epithelioid hemangioendotheliomaStable diseaseEpithelioid hemangioendotheliomaClinical benefitClinical benefit rateOpen-label studyPrimary end pointPoly (ADP-ribose) polymerase inhibitionDefective homologous recombination (HR) repairMesenchymal sarcomaObjective responsePartial responseClinical efficacyPatient populationBenefit rateCombination trialsPatientsSolid tumorsIDH1/2-mutant tumorsIDH1/2 mutationsPARP inhibitorsEnd pointPARP inhibitionTumorsOlaparib