2014
Genetic alterations in chondrosarcomas – keys to targeted therapies?
Samuel AM, Costa J, Lindskog DM. Genetic alterations in chondrosarcomas – keys to targeted therapies? Cellular Oncology 2014, 37: 95-105. PMID: 24458248, DOI: 10.1007/s13402-014-0166-8.Peer-Reviewed Original ResearchConceptsBenign cartilaginous lesionsCartilaginous lesionsMalignant transformationIhh/PTHrPTwo-hit scenarioPrimary bone tumorsGenetic alterationsDruggable molecular targetsKey genetic alterationsHuman tumor typesResultsCurrent dataBone tumorsMalignant tumorsSarcoma typesMalignant chondrosarcomasKey molecular changesNormal cell cycle controlTumor typesMalignant cellsChondrosarcoma developmentLesionsMolecular targetsTumorsEarly-stage eventsDifferentiation of chondrocytes
2010
Personalized approach to prostate cancer prognosis.
Donovan M, Costa J, Cordon-Cardo C. Personalized approach to prostate cancer prognosis. Minerva Urologica E Nefrologica 2010, 62: 231-9. PMID: 20940693.Peer-Reviewed Original ResearchConceptsProstate-specific antigenProstate needle biopsyNeedle biopsyProstate cancerProstatectomy specimenDiagnostic prostate needle biopsiesSerum prostate-specific antigenPatient-specific risk profileClinical-pathologic variablesExtent of diseaseManagement of patientsAncillary diagnostic studiesTreatment decision processPrognostic featuresTumor differentiationBreast cancerIndividual patientsCancer prognosisSpecific antigenClinical judgmentHealth outcomesMost urologistsTumor typesClinical decisionPatient attributes
1982
Histopathological features of rapidly progressing breast carcinoma in Tunisia: A study of 94 cases
Costa J, Webber B, Levine P, Muenz L, O'Conor G, Tabbane F, Belhassen S, Kamaraju L, Mourali N. Histopathological features of rapidly progressing breast carcinoma in Tunisia: A study of 94 cases. International Journal Of Cancer 1982, 30: 35-37. PMID: 6288578, DOI: 10.1002/ijc.2910300107.Peer-Reviewed Original ResearchConceptsHistological featuresCutaneous inflammatory infiltrateNuclear grade 3Breast carcinoma patientsCases of carcinomaPercentage of casesNumber of mitosesInflammatory carcinomaCarcinoma patientsHistopathological featuresInflammatory infiltrateTumor emboliNuclear gradeRapid progressionBreast carcinomaGrade 3Clinical classificationTumor typesBreast tissueCarcinomaPatientsCutaneous permeationBreastDermisPresent study