The Role of Sirtuin 3 in Radiation-Induced Long-Term Persistent Liver Injury
LoBianco FV, Krager KJ, Carter GS, Alam S, Yuan Y, Lavoie EG, Dranoff JA, Aykin-Burns N. The Role of Sirtuin 3 in Radiation-Induced Long-Term Persistent Liver Injury. Antioxidants 2020, 9: 409. PMID: 32403251, PMCID: PMC7278565, DOI: 10.3390/antiox9050409.Peer-Reviewed Original ResearchLong-term liver injuryLiver injurySirtuin 3Chronic responsesRole of SIRT3Mature bile ductsPersistent liver injuryAcute liver injuryTotal body irradiationUse of radiotherapyFibrotic factorsInflammatory infiltrationBody irradiationBile ductInflammatory chemokinesMale miceGy radiationHigher DNA damageMajor mitochondrial deacetylaseAbsence of SIRT3Mitochondrial deacetylaseInjuryGlutathione peroxidaseMouse liverGy IR