2018
Convergence and Divergence of CRH Amacrine Cells in Mouse Retinal Circuitry
Park SJH, Pottackal J, Ke JB, Jun NY, Rahmani P, Kim IJ, Singer JH, Demb JB. Convergence and Divergence of CRH Amacrine Cells in Mouse Retinal Circuitry. Journal Of Neuroscience 2018, 38: 3753-3766. PMID: 29572434, PMCID: PMC5895998, DOI: 10.1523/jneurosci.2518-17.2018.Peer-Reviewed Original ResearchConceptsAlpha ganglion cellsGanglion cell typesAmacrine cellsGanglion cellsCRH cellsAlpha cellsGABAergic synapsesInhibitory interneuronsExcitation/inhibition balanceCorticotropin-releasing hormoneCre transgenic miceFire action potentialsTonic excitatory driveCell typesBalance of excitationGABA releaseExcitatory circuitsRetinal circuitryExcitatory driveInhibition balanceInhibitory inputsMammalian retinaMouse retinaAction potentialsOptogenetic analyses
2016
Divisive suppression explains high-precision firing and contrast adaptation in retinal ganglion cells
Cui Y, Wang YV, Park SJ, Demb JB, Butts DA. Divisive suppression explains high-precision firing and contrast adaptation in retinal ganglion cells. ELife 2016, 5: e19460. PMID: 27841746, PMCID: PMC5108594, DOI: 10.7554/elife.19460.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAdaptation, OcularAnimalsMiceModels, NeurologicalRetinal Ganglion CellsVisual PerceptionConceptsExcitatory synaptic inputsSynaptic inputsGanglion cell functionContrast adaptationRetinal ganglion cellsGanglion cell inputsComplex neural circuitsGanglion cell outputCell-intrinsic mechanismsGanglion cellsDivisive interactionMouse retinaNeural circuitsSpike responsesCell functionDivisive suppressionSensory processingCell inputSpike generation mechanismMillisecond precisionVisual processingSpike trainsCell outputSuppressionRetina
2014
NMDA and AMPA receptors contribute similarly to temporal processing in mammalian retinal ganglion cells
Stafford BK, Manookin MB, Singer JH, Demb JB. NMDA and AMPA receptors contribute similarly to temporal processing in mammalian retinal ganglion cells. The Journal Of Physiology 2014, 592: 4877-4889. PMID: 25217374, PMCID: PMC4259533, DOI: 10.1113/jphysiol.2014.276543.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsCells, CulturedGuinea PigsKineticsReceptors, AMPAReceptors, N-Methyl-D-AspartateRetinal Ganglion CellsConceptsGanglion cellsNMDAR kineticsOFF alphaMammalian retinal ganglion cellsNMDA-type glutamate receptorsAMPAR-mediated responsesOFF alpha cellsGanglion cell typesRetinal ganglion cellsGuinea pig retinaNMDAR-mediated responsesBipolar cell pathwaysCell typesFast excitatory neurotransmissionGlutamatergic transmissionPresynaptic inhibitionGlutamate releaseSame synapsesSynaptic inhibitionGlutamate receptorsHz stimulationPostsynaptic AMPAExcitatory neurotransmissionSensory neuronsAMPA receptorsKainate Receptors Mediate Signaling in Both Transient and Sustained OFF Bipolar Cell Pathways in Mouse Retina
Borghuis BG, Looger LL, Tomita S, Demb JB. Kainate Receptors Mediate Signaling in Both Transient and Sustained OFF Bipolar Cell Pathways in Mouse Retina. Journal Of Neuroscience 2014, 34: 6128-6139. PMID: 24790183, PMCID: PMC4004803, DOI: 10.1523/jneurosci.4941-13.2014.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsDrug InteractionsExcitatory Amino Acid AntagonistsFemaleGlutamic AcidHexamethoniumIn Vitro TechniquesLightMaleMiceMice, Inbred C57BLNicotinic AntagonistsPatch-Clamp TechniquesPhotic StimulationPropionatesReceptors, Kainic AcidRetinaRetinal Bipolar CellsSignal TransductionVisual PathwaysConceptsGlutamate releaseBipolar cellsCone bipolar cell typesOFF bipolar cell pathwaysMouse bipolar cellsGanglion cell dendritesKainate-type glutamate receptorsBipolar cell typesLight-evoked responsesBipolar cell pathwaysGanglion cellsOFF layerCell dendritesReceptor mediatesGlutamate receptorsKainate receptorsAMPA receptorsTwo-photon imagingMouse retinaBipolar pathwayIntact circuitsOFF pathwaysElectrophysiological recordingsCircuit mechanismsReceptorsExcitatory Synaptic Inputs to Mouse On-Off Direction-Selective Retinal Ganglion Cells Lack Direction Tuning
Park SJ, Kim IJ, Looger LL, Demb JB, Borghuis BG. Excitatory Synaptic Inputs to Mouse On-Off Direction-Selective Retinal Ganglion Cells Lack Direction Tuning. Journal Of Neuroscience 2014, 34: 3976-3981. PMID: 24623775, PMCID: PMC3951696, DOI: 10.1523/jneurosci.5017-13.2014.Peer-Reviewed Original ResearchConceptsDirection-selective ganglion cellsOFF direction-selective ganglion cellsStarburst amacrine cellsGlutamate releaseBipolar cellsExcitatory currentsPreferred direction motionBipolar cell typesExcitatory synaptic inputsNull-direction inhibitionGABA-A receptorsWhole-cell recordingsNull-direction motionDSGC dendritesGABA releaseCholinergic inputAmacrine cellsGanglion cellsSynaptic mechanismsSynaptic inputsMammalian retinaMouse retinaIntensity-based glutamate-sensing fluorescent reporterDirection selectivityDirection tuning
2011
Delayed-Rectifier K Channels Contribute to Contrast Adaptation in Mammalian Retinal Ganglion Cells
Weick M, Demb JB. Delayed-Rectifier K Channels Contribute to Contrast Adaptation in Mammalian Retinal Ganglion Cells. Neuron 2011, 71: 166-179. PMID: 21745646, PMCID: PMC3134798, DOI: 10.1016/j.neuron.2011.04.033.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsGanglion cellsSubsequent depolarizationContrast adaptationOFF alpha ganglion cellsMammalian retinal ganglion cellsAlpha ganglion cellsGuinea pig retinaK channelsSuppress excitabilityPig retinaNa channel inactivationFiring responsesBrief depolarizationBrief hyperpolarizationRectifier K channelsVisual stimulationSomatic membrane patchesChannel inactivationDepolarizationPhysiological rangeIntrinsic mechanismHyperpolarizationCellsSalamander cellsSpectral and Temporal Sensitivity of Cone-Mediated Responses in Mouse Retinal Ganglion Cells
Wang YV, Weick M, Demb JB. Spectral and Temporal Sensitivity of Cone-Mediated Responses in Mouse Retinal Ganglion Cells. Journal Of Neuroscience 2011, 31: 7670-7681. PMID: 21613480, PMCID: PMC3122925, DOI: 10.1523/jneurosci.0629-11.2011.Peer-Reviewed Original ResearchConceptsCone-mediated responsesM-opsin expressionGanglion cellsMouse retinaMouse retinal ganglion cellsRod-mediated responsesSlower temporal processingRetinal ganglion cellsWild-type miceGanglion cell responsesCone-mediated visionMouse ganglion cellsVentral retinaDorsal retinaRod functionCone functionCell responsesS-opsinRetinaMiceMouse photoreceptorsExpression ratioLight stimulationPhotoreceptor typesTemporal processing
2008
Functional circuitry of visual adaptation in the retina
Demb JB. Functional circuitry of visual adaptation in the retina. The Journal Of Physiology 2008, 586: 4377-4384. PMID: 18617564, PMCID: PMC2614018, DOI: 10.1113/jphysiol.2008.156638.Peer-Reviewed Original ResearchConceptsPresynaptic bipolar cellsGanglion cellsReceptive field centerBipolar cellsGanglion cell receptive field centersPeripheral receptive fieldsBipolar cell inputsContrast adaptationRetinal ganglion cellsBipolar terminalsGlutamate releaseAmacrine cellsSynaptic outputMammalian retinaContrast stimulationFunctional circuitryCellular mechanismsSpike generationCell inputHyperpolarizationReceptive fieldsRetinaResponse saturationField centerCells
2007
Cellular Mechanisms for Direction Selectivity in the Retina
Demb JB. Cellular Mechanisms for Direction Selectivity in the Retina. Neuron 2007, 55: 179-186. PMID: 17640521, DOI: 10.1016/j.neuron.2007.07.001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDirection selectivityGanglion cellsDirection-selective ganglion cellsExcitatory circuitryInhibitory circuitryInhibitory interneuronsSynaptic inputsMammalian visual systemAction potentialsCellular mechanismsDirection preferenceMultiple sensory systemsDirection-selective mechanismsRetinaSensory systemsCellular Basis for Contrast Gain Control over the Receptive Field Center of Mammalian Retinal Ganglion Cells
Beaudoin DL, Borghuis BG, Demb JB. Cellular Basis for Contrast Gain Control over the Receptive Field Center of Mammalian Retinal Ganglion Cells. Journal Of Neuroscience 2007, 27: 2636-2645. PMID: 17344401, PMCID: PMC6672510, DOI: 10.1523/jneurosci.4610-06.2007.Peer-Reviewed Original ResearchConceptsReceptive field centerPresynaptic bipolar cellsGanglion cellsBipolar cellsAmacrine cellsGanglion cell receptive field centersContrast gain controlMammalian retinal ganglion cellsMammalian ganglion cellsRetinal ganglion cellsWhole-cell recordingsInhibitory neurotransmitter receptorsField centerVoltage-clamp conditionsInhibitory interneuronsSynaptic releaseNeurotransmitter receptorsCenter responseExtracellular recordingsPharmacological conditionsAdequate stimulationInhibitory conductanceCalcium bufferingSubthreshold responsesMembrane currents
2006
Presynaptic Mechanism for Slow Contrast Adaptation in Mammalian Retinal Ganglion Cells
Manookin MB, Demb JB. Presynaptic Mechanism for Slow Contrast Adaptation in Mammalian Retinal Ganglion Cells. Neuron 2006, 50: 453-464. PMID: 16675399, DOI: 10.1016/j.neuron.2006.03.039.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAdaptation, PhysiologicalAnimalsCalcium ChannelsContrast SensitivityGlutamic AcidGuinea PigsOrgan Culture TechniquesPhotic StimulationPresynaptic TerminalsReaction TimeReceptors, GABAReceptors, GlycineReceptors, Metabotropic GlutamateRetinal Bipolar CellsRetinal Ganglion CellsSynaptic TransmissionConceptsPresynaptic bipolar cellsRetinal ganglion cellsGanglion cellsBipolar cellsMammalian retinal ganglion cellsSlow contrast adaptationReduced glutamate releaseIntrinsic cellular propertiesIntrinsic cellular mechanismsCortical adaptationGlutamate releasePresynaptic mechanismsGlycine receptorsVisual neuronsAfterhyperpolarizationExcitatory conductancePotassium conductanceContrast adaptationCellular mechanismsCortical cellsNeuronsCellsCellular propertiesMGluRsSpatial stimuli
2005
Contrast Adaptation in Subthreshold and Spiking Responses of Mammalian Y-Type Retinal Ganglion Cells
Zaghloul KA, Boahen K, Demb JB. Contrast Adaptation in Subthreshold and Spiking Responses of Mammalian Y-Type Retinal Ganglion Cells. Journal Of Neuroscience 2005, 25: 860-868. PMID: 15673666, PMCID: PMC6725633, DOI: 10.1523/jneurosci.2782-04.2005.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsGanglion cellsIntracellular recordingsSubthreshold responsesY-type retinal ganglion cellsY-type ganglion cellsSynaptic mechanismsSynaptic inputsMammalian retinaSpiking responseExtracellular recordingsSubthreshold potentialsContrast sensitivitySpike outputSpike thresholdContrast adaptationSpike generationGain changesCellsRecordingsResponseApparent reductionRecording conditionsAbove effectsMean light level
2003
Different Circuits for ON and OFF Retinal Ganglion Cells Cause Different Contrast Sensitivities
Zaghloul KA, Boahen K, Demb JB. Different Circuits for ON and OFF Retinal Ganglion Cells Cause Different Contrast Sensitivities. Journal Of Neuroscience 2003, 23: 2645-2654. PMID: 12684450, PMCID: PMC6742092, DOI: 10.1523/jneurosci.23-07-02645.2003.Peer-Reviewed Original ResearchConceptsOFF cellsGanglion cellsSynaptic inputsContrast sensitivityExcitatory conductanceOFF retinal ganglion cellsOFF ganglion cellsBasal glutamate releaseRetinal ganglion cellsBrisk-transient cellsGuinea pig retinaBipolar terminalsPresynaptic circuitsGlutamate releaseIntracellular recordingsON pathwayPig retinaSubthreshold membrane potentialsLight incrementsL-APMembrane potentialCellsMean luminancePathwayRetina
2002
Multiple Mechanisms for Contrast Adaptation in the Retina
Demb JB. Multiple Mechanisms for Contrast Adaptation in the Retina. Neuron 2002, 36: 781-783. PMID: 12467580, DOI: 10.1016/s0896-6273(02)01100-5.Commentaries, Editorials and Letters
2001
Bipolar Cells Contribute to Nonlinear Spatial Summation in the Brisk-Transient (Y) Ganglion Cell in Mammalian Retina
Demb J, Zaghloul K, Haarsma L, Sterling P. Bipolar Cells Contribute to Nonlinear Spatial Summation in the Brisk-Transient (Y) Ganglion Cell in Mammalian Retina. Journal Of Neuroscience 2001, 21: 7447-7454. PMID: 11567034, PMCID: PMC6762908, DOI: 10.1523/jneurosci.21-19-07447.2001.Peer-Reviewed Original ResearchConceptsBipolar cellsGanglion cellsBrisk-transient ganglion cellsReceptive fieldsExcitatory postsynaptic potentialsGuinea pig retinaNonlinear spatial summationNonlinear receptive fieldsAmacrine cellsPostsynaptic potentialsPig retinaExcitatory mechanismsMammalian retinaY cellsLinear receptive fieldsSpatial summationBipolar inputRetinaCellsPeripheral componentsCentral componentAcetylcholineTetrodotoxinGABA
1999
Functional Circuitry of the Retinal Ganglion Cell's Nonlinear Receptive Field
Demb J, Haarsma L, Freed M, Sterling P. Functional Circuitry of the Retinal Ganglion Cell's Nonlinear Receptive Field. Journal Of Neuroscience 1999, 19: 9756-9767. PMID: 10559385, PMCID: PMC6782950, DOI: 10.1523/jneurosci.19-22-09756.1999.Peer-Reviewed Original ResearchConceptsGanglion cellsDendritic fieldsContrast-reversing gratingsNonlinear receptive fieldsOFF ganglion cellsReceptive fieldsCell dendritic fieldsRetinal ganglion cellsGuinea pig retinaBipolar cell responsesReceptive field mechanismsSurround responsesBipolar cellsPig retinaCell responsesFunctional circuitryL-APVisual stimuliMembrane potentialSingle classCellsResponseInterneuronsTetrodotoxinRetina