2016
Complexin 3 Increases the Fidelity of Signaling in a Retinal Circuit by Regulating Exocytosis at Ribbon Synapses
Mortensen LS, Park SJ, Ke JB, Cooper BH, Zhang L, Imig C, Löwel S, Reim K, Brose N, Demb JB, Rhee JS, Singer JH. Complexin 3 Increases the Fidelity of Signaling in a Retinal Circuit by Regulating Exocytosis at Ribbon Synapses. Cell Reports 2016, 15: 2239-2250. PMID: 27239031, PMCID: PMC5134263, DOI: 10.1016/j.celrep.2016.05.012.Peer-Reviewed Original ResearchConceptsRod bipolarsAsynchronous releaseAmacrine cell synapsesRetinal ganglion cellsRetinal pathwaysGanglion cellsCell synapsesRetinal circuitsRibbon synapsesMouse retinaMultivesicular releaseNeural circuitsComplexin proteinsSynapsesCircuit functionCplx3SignalingStudy linksReleaseExocytosisRB outputRetinaMind the Gap Junctions: The Importance of Electrical Synapses to Visual Processing
Demb JB, Singer JH. Mind the Gap Junctions: The Importance of Electrical Synapses to Visual Processing. Neuron 2016, 90: 207-209. PMID: 27100191, PMCID: PMC5751935, DOI: 10.1016/j.neuron.2016.04.007.Peer-Reviewed Original Research
2013
Adaptation to Background Light Enables Contrast Coding at Rod Bipolar Cell Synapses
Ke JB, Wang YV, Borghuis BG, Cembrowski MS, Riecke H, Kath WL, Demb JB, Singer JH. Adaptation to Background Light Enables Contrast Coding at Rod Bipolar Cell Synapses. Neuron 2013, 81: 388-401. PMID: 24373883, PMCID: PMC4267681, DOI: 10.1016/j.neuron.2013.10.054.Peer-Reviewed Original ResearchMeSH Keywords2-Amino-5-phosphonovalerateAdaptation, OcularAnimalsBiophysicsComputer SimulationExcitatory Amino Acid AntagonistsGlucosamine 6-Phosphate N-AcetyltransferaseGreen Fluorescent ProteinsIn Vitro TechniquesLightMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicModels, NeurologicalPatch-Clamp TechniquesQuinoxalinesRetinal Bipolar CellsRetinal Rod Photoreceptor CellsSynapsesVisual Pathways
2009
Activity acts locally
Demb JB, Feller MB. Activity acts locally. Nature 2009, 460: 961-963. PMID: 19693075, DOI: 10.1038/460961a.Peer-Reviewed Original Research
2008
Ultraweak Signals Can Cause Synaptic Depression and Adaptation
Demb JB, von Gersdorff H. Ultraweak Signals Can Cause Synaptic Depression and Adaptation. Neuron 2008, 57: 802-804. PMID: 18367079, DOI: 10.1016/j.neuron.2008.03.005.Commentaries, Editorials and Letters