2021
Photoreceptive Ganglion Cells Drive Circuits for Local Inhibition in the Mouse Retina
Pottackal J, Walsh HL, Rahmani P, Zhang K, Justice NJ, Demb JB. Photoreceptive Ganglion Cells Drive Circuits for Local Inhibition in the Mouse Retina. Journal Of Neuroscience 2021, 41: 1489-1504. PMID: 33397711, PMCID: PMC7896016, DOI: 10.1523/jneurosci.0674-20.2020.Peer-Reviewed Original ResearchMeSH KeywordsAmacrine CellsAnimalsCorticotropin-Releasing HormoneElectrophysiological PhenomenaExcitatory Postsynaptic PotentialsFemaleGamma-Aminobutyric AcidGap JunctionsMaleMiceMice, Inbred C57BLNeural InhibitionNeuronsOptogeneticsPhotoreceptor Cells, VertebrateRetinaRetinal Cone Photoreceptor CellsRetinal Ganglion CellsRetinal Rod Photoreceptor CellsRod OpsinsSynapsesConceptsGap junction-mediated electrical synapsesAmacrine cellsElectrical synapsesIpRGC activityGanglion cellsRetinal interneuronsRetinal circuitsPhotosensitive retinal ganglion cellsGABAergic amacrine cellsRetinal ganglion cellsWhole-cell recordingsSpecific RGC typesAbsence of rodsIpRGC typesRGC typesPharmacological blockadeRetinal neuronsMelanopsin expressionMature retinaMouse retinaSynaptic circuitsNeuronal circuitsInterneuronsOptogenetic stimulationLocal inhibition
2020
Connectomic analysis reveals an interneuron with an integral role in the retinal circuit for night vision
Park SJ, Lieberman EE, Ke JB, Rho N, Ghorbani P, Rahmani P, Jun NY, Lee HL, Kim IJ, Briggman KL, Demb JB, Singer JH. Connectomic analysis reveals an interneuron with an integral role in the retinal circuit for night vision. ELife 2020, 9: e56077. PMID: 32412412, PMCID: PMC7228767, DOI: 10.7554/elife.56077.Peer-Reviewed Original ResearchConceptsAII amacrine cellsProjection neuronsSingle interneuron typeConnectomic analysisBipolar cell pathwaysNovel neural circuitGABAergic cellsAmacrine cellsCentral neuronsGanglion cellsSynaptic layersRetinal circuitsInterneuron typesSurround inhibitionMouse retinaNight visionON responseExcitatory centerOptogenetic analysesNeural circuitsInhibitory surroundCell pathwaysRod photoreceptorsReceptive fieldsRb pathway
2017
Retina: Microcircuits for Daylight, Twilight, and Starlight Vision
Demb J, Singer J. Retina: Microcircuits for Daylight, Twilight, and Starlight Vision. 2017, 265-272. DOI: 10.1093/med/9780190636111.003.0021.Peer-Reviewed Original Research
2016
Complexin 3 Increases the Fidelity of Signaling in a Retinal Circuit by Regulating Exocytosis at Ribbon Synapses
Mortensen LS, Park SJ, Ke JB, Cooper BH, Zhang L, Imig C, Löwel S, Reim K, Brose N, Demb JB, Rhee JS, Singer JH. Complexin 3 Increases the Fidelity of Signaling in a Retinal Circuit by Regulating Exocytosis at Ribbon Synapses. Cell Reports 2016, 15: 2239-2250. PMID: 27239031, PMCID: PMC5134263, DOI: 10.1016/j.celrep.2016.05.012.Peer-Reviewed Original ResearchConceptsRod bipolarsAsynchronous releaseAmacrine cell synapsesRetinal ganglion cellsRetinal pathwaysGanglion cellsCell synapsesRetinal circuitsRibbon synapsesMouse retinaMultivesicular releaseNeural circuitsComplexin proteinsSynapsesCircuit functionCplx3SignalingStudy linksReleaseExocytosisRB outputRetinaMind the Gap Junctions: The Importance of Electrical Synapses to Visual Processing
Demb JB, Singer JH. Mind the Gap Junctions: The Importance of Electrical Synapses to Visual Processing. Neuron 2016, 90: 207-209. PMID: 27100191, PMCID: PMC5751935, DOI: 10.1016/j.neuron.2016.04.007.Peer-Reviewed Original ResearchConceptsChemical synapsesRetinal circuitsIssue of NeuronElectrical synapsesSynapsesGap junctionsVisual processing