2021
Preservation of vision after CaMKII-mediated protection of retinal ganglion cells
Guo X, Zhou J, Starr C, Mohns EJ, Li Y, Chen EP, Yoon Y, Kellner CP, Tanaka K, Wang H, Liu W, Pasquale LR, Demb JB, Crair MC, Chen B. Preservation of vision after CaMKII-mediated protection of retinal ganglion cells. Cell 2021, 184: 4299-4314.e12. PMID: 34297923, PMCID: PMC8530265, DOI: 10.1016/j.cell.2021.06.031.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsBrainCalcium-Calmodulin-Dependent Protein Kinase Type 2Cyclic AMP Response Element-Binding ProteinCytoprotectionDependovirusDisease Models, AnimalEnzyme ActivationGlaucomaMice, Inbred C57BLNeurotoxinsOptic Nerve InjuriesRetinal Ganglion CellsSignal TransductionVision, OcularConceptsRetinal ganglion cellsRGC survivalRGC somataGanglion cellsDiverse insultsRGC axon projectionOptic nerve injurySole output neuronsPreservation of visionElevated intraocular pressureIrreversible vision lossPathological statesExcitotoxic injuryNerve injuryGlaucoma modelIntraocular pressureRGC axonsVision lossVisual functionNormal retinaVisual cortexAxon projectionsGenetic deficiencyInjuryRetina
2017
These retinas are made for walkin'
Demb JB, Clark DA. These retinas are made for walkin'. Nature 2017, 546: 476-477. PMID: 28607483, DOI: 10.1038/nature22505.Peer-Reviewed Original Research
2016
Divisive suppression explains high-precision firing and contrast adaptation in retinal ganglion cells
Cui Y, Wang YV, Park SJ, Demb JB, Butts DA. Divisive suppression explains high-precision firing and contrast adaptation in retinal ganglion cells. ELife 2016, 5: e19460. PMID: 27841746, PMCID: PMC5108594, DOI: 10.7554/elife.19460.Peer-Reviewed Original ResearchConceptsExcitatory synaptic inputsSynaptic inputsGanglion cell functionContrast adaptationRetinal ganglion cellsGanglion cell inputsComplex neural circuitsGanglion cell outputCell-intrinsic mechanismsGanglion cellsDivisive interactionMouse retinaNeural circuitsSpike responsesCell functionDivisive suppressionSensory processingCell inputSpike generation mechanismMillisecond precisionVisual processingSpike trainsCell outputSuppressionRetinaComplexin 3 Increases the Fidelity of Signaling in a Retinal Circuit by Regulating Exocytosis at Ribbon Synapses
Mortensen LS, Park SJ, Ke JB, Cooper BH, Zhang L, Imig C, Löwel S, Reim K, Brose N, Demb JB, Rhee JS, Singer JH. Complexin 3 Increases the Fidelity of Signaling in a Retinal Circuit by Regulating Exocytosis at Ribbon Synapses. Cell Reports 2016, 15: 2239-2250. PMID: 27239031, PMCID: PMC5134263, DOI: 10.1016/j.celrep.2016.05.012.Peer-Reviewed Original ResearchConceptsRod bipolarsAsynchronous releaseAmacrine cell synapsesRetinal ganglion cellsRetinal pathwaysGanglion cellsCell synapsesRetinal circuitsRibbon synapsesMouse retinaMultivesicular releaseNeural circuitsComplexin proteinsSynapsesCircuit functionCplx3SignalingStudy linksReleaseExocytosisRB outputRetina
2015
Functional Circuitry of the Retina
Demb JB, Singer JH. Functional Circuitry of the Retina. Annual Review Of Vision Science 2015, 1: 263-289. PMID: 28532365, PMCID: PMC5749398, DOI: 10.1146/annurev-vision-082114-035334.Peer-Reviewed Original ResearchGanglion cellsImportant model systemCell typesSynaptic excitationMammalian retinaParallel pathwaysMouse retinaModel systemNeural circuitryFunctional circuitryRetinaRetinal computationCellular compositionOutput neuronsBasic mechanismsApparent complexityDynamic balanceCellsStraightforward mechanismSpeciesPathwayInterneuronsMechanismNeuronsBrain
2011
Spectral and Temporal Sensitivity of Cone-Mediated Responses in Mouse Retinal Ganglion Cells
Wang YV, Weick M, Demb JB. Spectral and Temporal Sensitivity of Cone-Mediated Responses in Mouse Retinal Ganglion Cells. Journal Of Neuroscience 2011, 31: 7670-7681. PMID: 21613480, PMCID: PMC3122925, DOI: 10.1523/jneurosci.0629-11.2011.Peer-Reviewed Original ResearchConceptsCone-mediated responsesM-opsin expressionGanglion cellsMouse retinaMouse retinal ganglion cellsRod-mediated responsesSlower temporal processingRetinal ganglion cellsWild-type miceGanglion cell responsesCone-mediated visionMouse ganglion cellsVentral retinaDorsal retinaRod functionCone functionCell responsesS-opsinRetinaMiceMouse photoreceptorsExpression ratioLight stimulationPhotoreceptor typesTemporal processing
2010
Neurons show their true colours
Demb JB, Brainard DH. Neurons show their true colours. Nature 2010, 467: 670-671. PMID: 20930837, DOI: 10.1038/467670b.Peer-Reviewed Original ResearchInformation Processing: Contrast Sensitivity
Manookin M, Demb J. Information Processing: Contrast Sensitivity. 2010, 344-348. DOI: 10.1016/b978-0-12-374203-2.00199-8.Chapters
2009
Activity acts locally
Demb JB, Feller MB. Activity acts locally. Nature 2009, 460: 961-963. PMID: 19693075, DOI: 10.1038/460961a.Peer-Reviewed Original Research
2008
Functional circuitry of visual adaptation in the retina
Demb JB. Functional circuitry of visual adaptation in the retina. The Journal Of Physiology 2008, 586: 4377-4384. PMID: 18617564, PMCID: PMC2614018, DOI: 10.1113/jphysiol.2008.156638.Peer-Reviewed Original ResearchConceptsPresynaptic bipolar cellsGanglion cellsReceptive field centerBipolar cellsGanglion cell receptive field centersPeripheral receptive fieldsBipolar cell inputsContrast adaptationRetinal ganglion cellsBipolar terminalsGlutamate releaseAmacrine cellsSynaptic outputMammalian retinaContrast stimulationFunctional circuitryCellular mechanismsSpike generationCell inputHyperpolarizationReceptive fieldsRetinaResponse saturationField centerCellsUltraweak Signals Can Cause Synaptic Depression and Adaptation
Demb JB, von Gersdorff H. Ultraweak Signals Can Cause Synaptic Depression and Adaptation. Neuron 2008, 57: 802-804. PMID: 18367079, DOI: 10.1016/j.neuron.2008.03.005.Commentaries, Editorials and Letters
2007
Cellular Mechanisms for Direction Selectivity in the Retina
Demb JB. Cellular Mechanisms for Direction Selectivity in the Retina. Neuron 2007, 55: 179-186. PMID: 17640521, DOI: 10.1016/j.neuron.2007.07.001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDirection selectivityGanglion cellsDirection-selective ganglion cellsExcitatory circuitryInhibitory circuitryInhibitory interneuronsSynaptic inputsMammalian visual systemAction potentialsCellular mechanismsDirection preferenceMultiple sensory systemsDirection-selective mechanismsRetinaSensory systems
2006
Making selective 'cone-ections'
Demb JB. Making selective 'cone-ections'. Nature Neuroscience 2006, 9: 595-596. PMID: 16639404, DOI: 10.1038/nn0506-595.Commentaries, Editorials and Letters
2003
Different Circuits for ON and OFF Retinal Ganglion Cells Cause Different Contrast Sensitivities
Zaghloul KA, Boahen K, Demb JB. Different Circuits for ON and OFF Retinal Ganglion Cells Cause Different Contrast Sensitivities. Journal Of Neuroscience 2003, 23: 2645-2654. PMID: 12684450, PMCID: PMC6742092, DOI: 10.1523/jneurosci.23-07-02645.2003.Peer-Reviewed Original ResearchConceptsOFF cellsGanglion cellsSynaptic inputsContrast sensitivityExcitatory conductanceOFF retinal ganglion cellsOFF ganglion cellsBasal glutamate releaseRetinal ganglion cellsBrisk-transient cellsGuinea pig retinaBipolar terminalsPresynaptic circuitsGlutamate releaseIntracellular recordingsON pathwayPig retinaSubthreshold membrane potentialsLight incrementsL-APMembrane potentialCellsMean luminancePathwayRetina
2002
Multiple Mechanisms for Contrast Adaptation in the Retina
Demb JB. Multiple Mechanisms for Contrast Adaptation in the Retina. Neuron 2002, 36: 781-783. PMID: 12467580, DOI: 10.1016/s0896-6273(02)01100-5.Commentaries, Editorials and Letters
2001
Cellular Basis for the Response to Second-Order Motion Cues in Y Retinal Ganglion Cells
Demb J, Zaghloul K, Sterling P. Cellular Basis for the Response to Second-Order Motion Cues in Y Retinal Ganglion Cells. Neuron 2001, 32: 711-721. PMID: 11719210, DOI: 10.1016/s0896-6273(01)00484-6.Peer-Reviewed Original ResearchConceptsGanglion cellsEPSP/IPSP sequencesY cellsOFF ganglion cellsY ganglion cellsRetinal ganglion cellsSecond-order motion cuesSecond-order motion stimuliDendritic fieldsInhibitory effectCell inhibitionCellular basisMotion stimuliCortical cellsSecond-order motionCellsPerceive motionResponseTetrodotoxinCortexRetinaBipolar Cells Contribute to Nonlinear Spatial Summation in the Brisk-Transient (Y) Ganglion Cell in Mammalian Retina
Demb J, Zaghloul K, Haarsma L, Sterling P. Bipolar Cells Contribute to Nonlinear Spatial Summation in the Brisk-Transient (Y) Ganglion Cell in Mammalian Retina. Journal Of Neuroscience 2001, 21: 7447-7454. PMID: 11567034, PMCID: PMC6762908, DOI: 10.1523/jneurosci.21-19-07447.2001.Peer-Reviewed Original ResearchConceptsBipolar cellsGanglion cellsBrisk-transient ganglion cellsReceptive fieldsExcitatory postsynaptic potentialsGuinea pig retinaNonlinear spatial summationNonlinear receptive fieldsAmacrine cellsPostsynaptic potentialsPig retinaExcitatory mechanismsMammalian retinaY cellsLinear receptive fieldsSpatial summationBipolar inputRetinaCellsPeripheral componentsCentral componentAcetylcholineTetrodotoxinGABA
1999
Functional Circuitry of the Retinal Ganglion Cell's Nonlinear Receptive Field
Demb J, Haarsma L, Freed M, Sterling P. Functional Circuitry of the Retinal Ganglion Cell's Nonlinear Receptive Field. Journal Of Neuroscience 1999, 19: 9756-9767. PMID: 10559385, PMCID: PMC6782950, DOI: 10.1523/jneurosci.19-22-09756.1999.Peer-Reviewed Original ResearchConceptsGanglion cellsDendritic fieldsContrast-reversing gratingsNonlinear receptive fieldsOFF ganglion cellsReceptive fieldsCell dendritic fieldsRetinal ganglion cellsGuinea pig retinaBipolar cell responsesReceptive field mechanismsSurround responsesBipolar cellsPig retinaCell responsesFunctional circuitryL-APVisual stimuliMembrane potentialSingle classCellsResponseInterneuronsTetrodotoxinRetina