2023
Brn3b regulates the formation of fear-related midbrain circuits and defensive responses to visual threat
Lee H, Weinberg-Wolf H, Lee H, Lee T, Conte J, Godoy-Parejo C, Demb J, Rudenko A, Kim IJ. Brn3b regulates the formation of fear-related midbrain circuits and defensive responses to visual threat. PLOS Biology 2023, 21: e3002386. PMID: 37983249, PMCID: PMC10695396, DOI: 10.1371/journal.pbio.3002386.Peer-Reviewed Original ResearchConceptsTranscription factor Brn3bLoss of neuronsVisual threatLateral posterior nucleusMutant mice displayDefensive responsesDefensive freezing responsesPosterior nucleusTachykinin 2Mice displayMidbrain circuitVisual circuitsNeural circuitryBrn3bSpecific genetic componentsFreezing responseFear-associated behaviorsSocial isolationTac2Behavioral phenotypesMolecular mechanismsFunctional organizationGenetic componentResponseSimilar mechanism
2016
Parallel Computations in Insect and Mammalian Visual Motion Processing
Clark DA, Demb JB. Parallel Computations in Insect and Mammalian Visual Motion Processing. Current Biology 2016, 26: r1062-r1072. PMID: 27780048, PMCID: PMC5108051, DOI: 10.1016/j.cub.2016.08.003.Peer-Reviewed Original ResearchConceptsOff-pathway structuresNeural circuitsMammalian neural circuitsMolecular mechanismsPathway structureDifferent neural circuitsMolecular features distinguish ten neuronal types in the mouse superficial superior colliculus
Byun H, Kwon S, Ahn HJ, Liu H, Forrest D, Demb JB, Kim IJ. Molecular features distinguish ten neuronal types in the mouse superficial superior colliculus. The Journal Of Comparative Neurology 2016, 524: 2300-2321. PMID: 26713509, PMCID: PMC4892959, DOI: 10.1002/cne.23952.Peer-Reviewed Original ResearchConceptsSpecific cell typesCell typesMolecular markersEts variant gene 1Distinct expression patternsSuperior colliculusMouse SSCsTranscription factorsCadherin-7Retinoid-related orphan receptor βContactin-3Cell adhesion moleculeProtein 3BNeuronal typesSSC neuronsExpression patternsGene expressionMolecular mechanismsProtocadherin 20Gene 1Binding proteinCadherin-6Netrin-G2Calcium binding proteinMolecular families