2021
Bronchoalveolar Lavage Fluid Reflects a TH1-CD21low B-Cell Interaction in CVID-Related Interstitial Lung Disease
Friedmann D, Unger S, Keller B, Rakhmanov M, Goldacker S, Zissel G, Frye B, Schupp J, Prasse A, Warnatz K. Bronchoalveolar Lavage Fluid Reflects a TH1-CD21low B-Cell Interaction in CVID-Related Interstitial Lung Disease. Frontiers In Immunology 2021, 11: 616832. PMID: 33613543, PMCID: PMC7892466, DOI: 10.3389/fimmu.2020.616832.Peer-Reviewed Original ResearchConceptsInterstitial lung diseaseCommon variable immunodeficiencyBAL fluidB cellsLung diseaseT cellsImmune dysregulationBronchoalveolar lavageHealthy donorsClass-switched memory B cellsLymphocytic interstitial lung diseaseProgressive interstitial lung diseaseLevels of BAFFLike cell subsetSystemic immune dysregulationRegulatory T cellsVideo-assisted thoracoscopyBronchoalveolar lavage fluidT cell populationsPotential immune mechanismsLevels of APRILMemory B cellsB cell interactionsFlow cytometric profilingPotential treatment target
2017
Preferential Reduction of Circulating Innate Lymphoid Cells Type 2 in Patients with Common Variable Immunodeficiency with Secondary Complications Is Part of a Broader Immune Dysregulation
Friedmann D, Keller B, Harder I, Schupp J, Tanriver Y, Unger S, Warnatz K. Preferential Reduction of Circulating Innate Lymphoid Cells Type 2 in Patients with Common Variable Immunodeficiency with Secondary Complications Is Part of a Broader Immune Dysregulation. Journal Of Clinical Immunology 2017, 37: 759-769. PMID: 28936778, DOI: 10.1007/s10875-017-0444-0.Peer-Reviewed Original ResearchConceptsInnate lymphoid cellsCommon variable immunodeficiencyTh1-like T cellsCD21low B cellsCVID patientsT cellsSecondary complicationsVariable immunodeficiencyILC phenotypesB cellsInnate lymphoid cells type 2T helper cell subsetsBroad immune dysregulationThird of patientsCD4 T cellsCell type 2Helper cell subsetsInflammatory organ diseaseAdaptive immune systemAutoimmune manifestationsImmune dysregulationTh1 shiftCell subsetsImmunological phenotypePeripheral blood