2001
Absence of Functional Type 1 Parathyroid Hormone (PTH)/PTH-Related Protein Receptors in Humans Is Associated with Abnormal Breast Development and Tooth Impaction1
Wysolmerski J, Cormier S, Philbrick W, Dann P, Zhang J, Roume J, Delezoide A, Silve C. Absence of Functional Type 1 Parathyroid Hormone (PTH)/PTH-Related Protein Receptors in Humans Is Associated with Abnormal Breast Development and Tooth Impaction1. The Journal Of Clinical Endocrinology & Metabolism 2001, 86: 1788-1794. PMID: 11297619, DOI: 10.1210/jcem.86.4.7404.Peer-Reviewed Original ResearchConceptsParathyroid hormoneHuman breastBreast developmentType 1 PTH/PTHrP receptorBlomstrand chondrodysplasiaPTH/PTHrP receptorAbnormal breast developmentBone formationTooth developmentNormal human fetusesTooth impactionPTHrP receptorEndochondral bone formationTransgenic miceAlveolar boneHuman fetusesEndochondral bone developmentBreastSevere abnormalitiesEpithelial-mesenchymal interactionsLethal formMammary glandFetusesBone developmentTeeth
2000
Activation of PTHrP Gene Expression in Squamous Carcinoma Cell Lines by Mutant Isoforms of the Tumor Suppressor p53
Foley J, King CS, Jiménez JA, Wysolmerski JJ, Philbrick WM. Activation of PTHrP Gene Expression in Squamous Carcinoma Cell Lines by Mutant Isoforms of the Tumor Suppressor p53. Oncology Research Featuring Preclinical And Clinical Cancer Therapeutics 2000, 12: 71-81. PMID: 11132926, DOI: 10.3727/096504001108747549.Peer-Reviewed Original ResearchAllelesAnimalsBlotting, WesternCarcinoma, Squamous CellCodonGene Expression Regulation, NeoplasticGenes, p53HumansMiceMutagenesis, Site-DirectedMutationMutation, MissenseParathyroid Hormone-Related ProteinPlasmidsPoint MutationPrecipitin TestsPromoter Regions, GeneticProtein ConformationProtein DenaturationProtein IsoformsProteinsRNA, MessengerTransfectionTumor Cells, CulturedTumor Suppressor Protein p53
1999
Regulation of parathyroid hormone-related protein gene expression in murine keratinocytes by E1A isoforms: a role for basal promoter and Ets-1 site
Foley J, Wysolmerski J, Missero C, King C, Philbrick W. Regulation of parathyroid hormone-related protein gene expression in murine keratinocytes by E1A isoforms: a role for basal promoter and Ets-1 site. Molecular And Cellular Endocrinology 1999, 156: 13-23. PMID: 10612419, DOI: 10.1016/s0303-7207(99)00151-3.Peer-Reviewed Original ResearchMeSH KeywordsAdenovirus E1A ProteinsAnimalsBase SequenceBinding SitesCell Line, TransformedEnhancer Elements, GeneticGene Expression RegulationGenes, rasGenes, ReporterKeratinocytesLuciferasesMiceParathyroid HormoneParathyroid Hormone-Related ProteinPromoter Regions, GeneticProtein IsoformsProteinsProto-Oncogene Protein c-ets-1Proto-Oncogene ProteinsProto-Oncogene Proteins c-etsRNA, MessengerTranscription FactorsTranscription, GeneticConceptsGene expressionBasal promoterReporter constructsEts-1 siteMinimal promoter regionProtein gene expressionTransient transfection assaysReporter gene activityRepressor domainE1A oncoproteinGene activityRas transformationE1A isoformsMurine keratinocyte lineSite upstreamReporter geneTransfection assaysPromoter regionParathyroid hormone-related protein gene expression