TOPGAL Mice Show That the Canonical Wnt Signaling Pathway Is Active During Bone Development and Growth and Is Activated by Mechanical Loading In Vitro*
Hens JR, Wilson KM, Dann P, Chen X, Horowitz MC, Wysolmerski JJ. TOPGAL Mice Show That the Canonical Wnt Signaling Pathway Is Active During Bone Development and Growth and Is Activated by Mechanical Loading In Vitro*. Journal Of Bone And Mineral Research 2005, 20: 1103-1113. PMID: 15940363, DOI: 10.1359/jbmr.050210.Peer-Reviewed Original ResearchConceptsTOPGAL miceBone developmentCanonical WntMature skeletonNeonatal bone developmentCanonical Wnt Signaling PathwayExpression of WntActivation of WntWnt Signaling PathwayX-gal stainingCalvarial cellsT-cell factorBone massCanonical Wnt activityCanonical Wnt signalingPrimary calvarial cell culturesMiceAnabolic activityPrimary calvarial cellsRT-PCRCell factorCultured calvarial cellsNeonatal skeletonCollagen ISignaling pathways