2022
Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 1: Technical Considerations and Perfusion and Neuronal Imaging.
Stendahl JC, Kwan JM, Pucar D, Sadeghi MM. Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 1: Technical Considerations and Perfusion and Neuronal Imaging. Journal Of Nuclear Medicine 2022, 63: 649-658. PMID: 35487563, DOI: 10.2967/jnumed.121.263506.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAtherosclerosisHumansPerfusionPositron-Emission TomographyRadiopharmaceuticalsTomography, Emission-Computed, Single-PhotonConceptsUnmet diagnostic needsCardiovascular medicineNeuronal imagingImaging of inflammationHeart failureValvular diseaseTechnical considerationsDiagnostic needsCardiac amyloidosisUnmet ClinicalNew radiotracersCardiovascular imagingPersonalized therapyPerfusion tracerPET perfusion tracerThrombosisRadiotracer developmentRadiotracerPerfusionF-FlurpiridazImagingReviewMedicineKey technical considerationsMolecular characterization
2016
Optimized and Automated Radiosynthesis of [18F]DHMT for Translational Imaging of Reactive Oxygen Species with Positron Emission Tomography
Zhang W, Cai Z, Li L, Ropchan J, Lim K, Boutagy NE, Wu J, Stendahl JC, Chu W, Gropler R, Sinusas AJ, Liu C, Huang Y. Optimized and Automated Radiosynthesis of [18F]DHMT for Translational Imaging of Reactive Oxygen Species with Positron Emission Tomography. Molecules 2016, 21: 1696. PMID: 27941676, PMCID: PMC5505691, DOI: 10.3390/molecules21121696.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDogsFluorine RadioisotopesPositron-Emission TomographyRadiopharmaceuticalsTranslational Research, Biomedical
2015
Nanoparticles for Cardiovascular Imaging and Therapeutic Delivery, Part 2: Radiolabeled Probes
Stendahl JC, Sinusas AJ. Nanoparticles for Cardiovascular Imaging and Therapeutic Delivery, Part 2: Radiolabeled Probes. Journal Of Nuclear Medicine 2015, 56: 1637-1641. PMID: 26294304, PMCID: PMC4934892, DOI: 10.2967/jnumed.115.164145.BooksConceptsSmall molecule agentsTherapeutic deliveryNanoparticlesMolecular imagingDistinct propertiesTherapeutic applicationsFurther technologic developmentsTheranosticsAddress safety concernsProbeFunctional versatilitySignificant potentialAgentsClinical translationVersatilityPropertiesApplicationsPreclinical cardiovascular researchCurrent examplesNanoparticles for Cardiovascular Imaging and Therapeutic Delivery, Part 1: Compositions and Features
Stendahl JC, Sinusas AJ. Nanoparticles for Cardiovascular Imaging and Therapeutic Delivery, Part 1: Compositions and Features. Journal Of Nuclear Medicine 2015, 56: 1469-1475. PMID: 26272808, PMCID: PMC4934895, DOI: 10.2967/jnumed.115.160994.BooksMeSH KeywordsCardiovascular SystemDrug Delivery SystemsHumansMolecular ImagingMultimodal ImagingNanoparticlesParticle SizeRadionuclide ImagingRadiopharmaceuticalsConceptsTherapeutic deliveryMultifunctional imaging agentsTargeted molecular imagingTunable propertiesSmall moleculesVersatile platformNanoparticlesUnique propertiesSmall molecule agentsImaging agentIntriguing attributesClinical translationMolecular imagingPharmacokinetic limitationsPropertiesElimination propertiesDiscusses challengesScope of applicationMoleculesHigh-resolution imaging modalityDeliveryMicroparticlesAgentsBiodistributionPlatform