T-Cell Profile in Adipose Tissue Is Associated With Insulin Resistance and Systemic Inflammation in Humans
McLaughlin T, Liu LF, Lamendola C, Shen L, Morton J, Rivas H, Winer D, Tolentino L, Choi O, Zhang H, Hui Yen Chng M, Engleman E. T-Cell Profile in Adipose Tissue Is Associated With Insulin Resistance and Systemic Inflammation in Humans. Arteriosclerosis Thrombosis And Vascular Biology 2014, 34: 2637-2643. PMID: 25341798, PMCID: PMC4445971, DOI: 10.1161/atvbaha.114.304636.Peer-Reviewed Original ResearchConceptsCD8 T cellsSubcutaneous adipose tissueT cell profileInsulin resistanceT cellsAdipose tissueSystemic inflammationPeripheral bloodPlasma high-sensitivity C-reactive protein concentrationsHigh-sensitivity C-reactive protein concentrationsAnti-inflammatory T cellsAnti-inflammatory interleukin-10C-reactive protein concentrationsDiet-induced obese miceObesity-associated metabolic diseasesInsulin-mediated glucose disposalProinflammatory T helperPlasma interleukin-6T cell subsetsInsulin suppression testT-cell phenotypeSystemic insulin resistanceAdipose tissue biopsiesObese human subjectsReal-time polymerase chain reaction