2019
1768-P: Inflammation in Visceral and Subcutaneous Fat and Human Insulin Resistance
MCLAUGHLIN T, ZANLEY E, PETLURA C, TOLENTINO L, CHOI O, CHUANG J, XU Y, MORTON J, ENGLEMAN E. 1768-P: Inflammation in Visceral and Subcutaneous Fat and Human Insulin Resistance. Diabetes 2019, 68 DOI: 10.2337/db19-1768-p.Peer-Reviewed Original ResearchVisceral adipose tissueInsulin resistanceWhole-body insulin sensitivityBariatric surgery patientsImmune cell profilesSystemic insulin resistanceTotal fat massAmerican Heart AssociationPlasma glucose testSystemic glucose metabolismHuman insulin resistanceSurgery patientsInflammation contributesHeart AssociationCytokine releaseImmune cellsInsulin sensitivityMacrophage numbersFat massBacterial antigensAdipocyte stressGlucose testGlucose metabolismHuman studiesAdipose tissue
2017
Adipose tissue macrophages impair preadipocyte differentiation in humans
Liu LF, Craig CM, Tolentino LL, Choi O, Morton J, Rivas H, Cushman SW, Engleman EG, McLaughlin T. Adipose tissue macrophages impair preadipocyte differentiation in humans. PLOS ONE 2017, 12: e0170728. PMID: 28151993, PMCID: PMC5289462, DOI: 10.1371/journal.pone.0170728.Peer-Reviewed Original ResearchConceptsImpaired adipocyte differentiationSystemic insulin resistanceInsulin resistanceAdipocyte differentiationPreadipocyte differentiationMacrophage removalImpaired preadipocyte differentiationProinflammatory immune cellsAdipose tissue inflammationAbsence of CD14Insulin-resistant humansAdipose tissue samplesOil Red ODifferentiation of preadipocytesBariatric surgeryProinflammatory cytokinesInflammatory cytokinesTissue inflammationImmune cellsCytokine secretionAdiponectin secretionAdipogenic gene expressionPhysiologic mechanismsAdipose tissueVAT adipocytes