2020
Randomized controlled clinical study evaluating the efficacy and safety of intratumoral treatment of canine mast cell tumors with tigilanol tiglate (EBC‐46)
De Ridder TR, Campbell JE, Burke‐Schwarz C, Clegg D, Elliot EL, Geller S, Kozak W, Pittenger ST, Pruitt JB, Riehl J, White J, Wiest ML, Johannes CM, Morton J, Jones PD, Schmidt PF, Gordon V, Reddell P. Randomized controlled clinical study evaluating the efficacy and safety of intratumoral treatment of canine mast cell tumors with tigilanol tiglate (EBC‐46). Journal Of Veterinary Internal Medicine 2020, 35: 415-429. PMID: 32542733, PMCID: PMC7848366, DOI: 10.1111/jvim.15806.Peer-Reviewed Original ResearchConceptsMast cell tumorsComplete responseControl dogsAdverse eventsIntratumoral treatmentTigilanol tiglateCell tumorsClinical studiesTumor volumeModified Response Evaluation CriteriaTT treatmentOverall complete responseResponse Evaluation CriteriaCanine mast cell tumorsPhase 1Quality of lifeConcomitant medicationsTumor resolutionLocal treatmentTreatment responseSolid tumorsDogsTumorsTreatmentEfficacy
2019
Employing Enhanced Recovery Goals in Bariatric Surgery (ENERGY): a national quality improvement project using the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program
Brethauer SA, Grieco A, Fraker T, Evans-Labok K, Smith A, McEvoy MD, Saber AA, Morton JM, Petrick A. Employing Enhanced Recovery Goals in Bariatric Surgery (ENERGY): a national quality improvement project using the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program. Surgery For Obesity And Related Diseases 2019, 15: 1977-1989. PMID: 31640906, DOI: 10.1016/j.soard.2019.08.024.Peer-Reviewed Original ResearchConceptsBariatric Surgery AccreditationLength of stayBariatric surgeryReoperation rateNational quality improvement projectBariatric Surgery projectPrimary bariatric procedureOverall adverse eventsBariatric surgery patientsEnhanced recovery pathwayEnhanced recovery protocolQuality improvement projectQuality Improvement ProgramFinal analytic sampleBariatric proceduresOverall morbidityAdverse eventsReadmission ratesSurgery patientsPrivate practice programsSignificant associationRecovery pathwaysSurgery projectAnalytic sampleProcess measuresPreoperative weight loss: is waiting longer before bariatric surgery more effective?
Eng V, Garcia L, Khoury H, Morton J, Azagury D. Preoperative weight loss: is waiting longer before bariatric surgery more effective? Surgery For Obesity And Related Diseases 2019, 15: 951-957. PMID: 31104959, DOI: 10.1016/j.soard.2019.03.012.Peer-Reviewed Original ResearchConceptsBody mass indexWeight lossBariatric surgeryMass indexConsultation visitSupervised weight loss programAverage body mass indexPreoperative wait timeSleeve gastrectomy patientsGastric bypass patientsPostoperative weight lossRate of complicationsDelay of treatmentWeight loss programSingle academic institutionInitial consultation visitAdverse surgical eventsSignificant long-term benefitWait timePreoperative percentageGastrectomy patientsGastric bypassLaparoscopic RouxBypass patientsAdverse events
2018
Which postoperative complications matter most after bariatric surgery? Prioritizing quality improvement efforts to improve national outcomes
Daigle CR, Brethauer SA, Tu C, Petrick AT, Morton JM, Schauer PR, Aminian A. Which postoperative complications matter most after bariatric surgery? Prioritizing quality improvement efforts to improve national outcomes. Surgery For Obesity And Related Diseases 2018, 14: 652-657. PMID: 29503096, DOI: 10.1016/j.soard.2018.01.008.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnastomotic LeakBariatric SurgeryCritical CareFemaleHealth PrioritiesHumansMaleMiddle AgedPatient ReadmissionPostoperative ComplicationsPostoperative HemorrhageProspective StudiesReoperationRisk AssessmentSurgical Wound InfectionTreatment OutcomeUrinary Tract InfectionsVenous ThromboembolismConceptsPopulation attributable fractionBariatric surgeryAttributable fractionSpecific complicationsIntensive care unit admissionQuality Improvement Program databaseBariatric surgery complicationsPrimary bariatric procedureCare unit admissionEnd-organ dysfunctionAdjustable gastric bandingImprovement Program databaseBariatric Surgery AccreditationUrinary tract infectionParticipant Use FileKey clinical outcomesKey surgical outcomesQuality improvement effortsUnit admissionGastric bandingGastric bypassPostoperative complicationsSleeve gastrectomyAdverse eventsBariatric procedures
2017
Comparative effectiveness of primary bariatric operations in the United States
Sudan R, Maciejewski ML, Wilk AR, Nguyen NT, Ponce J, Morton JM. Comparative effectiveness of primary bariatric operations in the United States. Surgery For Obesity And Related Diseases 2017, 13: 826-834. PMID: 28236529, DOI: 10.1016/j.soard.2017.01.021.Peer-Reviewed Original ResearchConceptsBPD/DSPrimary bariatric operationsBariatric surgery centerBariatric operationsAdverse eventsSurgery centersBody mass index unitWeight lossCo-morbidity resolutionMore adverse eventsMultiple surgical centersSerious adverse eventsType 2 diabetesGreater weight lossLarge multisite cohortCurrent bariatric operationsT2D resolutionComorbidity resolutionBaseline characteristicsGastric bypassDuodenal switchSurgical centersInverse probability weightingMultisite cohortOdds ratio
2016
Effect of Vagal Nerve Blockade on Moderate Obesity with an Obesity-Related Comorbid Condition: the ReCharge Study
Morton JM, Shah SN, Wolfe BM, Apovian CM, Miller CJ, Tweden KS, Billington CJ, Shikora SA. Effect of Vagal Nerve Blockade on Moderate Obesity with an Obesity-Related Comorbid Condition: the ReCharge Study. Obesity Surgery 2016, 26: 983-989. PMID: 27048437, PMCID: PMC4831996, DOI: 10.1007/s11695-016-2143-y.Peer-Reviewed Original ResearchConceptsObesity-related comorbid conditionsBody mass indexModerate obesityComorbid conditionsPercentage excess weight lossWeight lossImplant site painVagal nerve blockadeCommon adverse eventsExcess weight lossObesity-related comorbiditiesWeight management counselingType 2 diabetesGreater weight lossSite painAdverse eventsBlockade therapyPrespecified subgroupsSevere obesitySham deviceMass indexNerve blockadeSleep apneaSafety profileClinical trials
2014
Morbidity, Mortality, and Weight Loss Outcomes After Reoperative Bariatric Surgery in the USA
Sudan R, Nguyen NT, Hutter MM, Brethauer SA, Ponce J, Morton JM. Morbidity, Mortality, and Weight Loss Outcomes After Reoperative Bariatric Surgery in the USA. Journal Of Gastrointestinal Surgery 2014, 19: 171-179. PMID: 25186073, DOI: 10.1007/s11605-014-2639-5.Peer-Reviewed Original ResearchConceptsReoperative bariatric surgerySevere adverse eventsBariatric operationsPrimary operationAdverse eventsBariatric surgeryMortality ratePercent excess weight lossBariatric Outcomes Longitudinal DatabaseEfficacy of reoperationInitial bariatric operationsExcess weight lossBariatric surgery patientsWeight loss outcomesLength of stayMore African AmericansLarge national studyComplication rateSurgery patientsConversion groupPrimary procedureLoss outcomesReoperationCorrective operationWeight lossEffect of Reversible Intermittent Intra-abdominal Vagal Nerve Blockade on Morbid Obesity: The ReCharge Randomized Clinical Trial
Ikramuddin S, Blackstone RP, Brancatisano A, Toouli J, Shah SN, Wolfe BM, Fujioka K, Maher JW, Swain J, Que FG, Morton JM, Leslie DB, Brancatisano R, Kow L, O’Rourke R, Deveney C, Takata M, Miller CJ, Knudson MB, Tweden KS, Shikora SA, Sarr MG, Billington CJ. Effect of Reversible Intermittent Intra-abdominal Vagal Nerve Blockade on Morbid Obesity: The ReCharge Randomized Clinical Trial. JAMA 2014, 312: 915-922. PMID: 25182100, DOI: 10.1001/jama.2014.10540.Peer-Reviewed Original ResearchConceptsExcess weight lossNerve block groupPrimary safety objectiveWeight lossMorbid obesityAdverse eventsSham groupClinical trialsEfficacy objectiveMean percentage excess weight lossBlock groupPercentage excess weight lossSerious adverse event ratesSham-controlled clinical trialSham device groupVagal nerve blockadeWeight management educationSerious adverse eventsBariatric surgery resultsLong-term morbidityAdverse event ratesObesity-related conditionsNerve block therapyBody mass indexAbdominal painIs Ambulatory Laparoscopic Roux-En-Y Gastric Bypass Associated With Higher Adverse Events?
Morton JM, Winegar D, Blackstone R, Wolfe B. Is Ambulatory Laparoscopic Roux-En-Y Gastric Bypass Associated With Higher Adverse Events? Annals Of Surgery 2014, 259: 286-292. PMID: 24169190, DOI: 10.1097/sla.0000000000000227.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAmbulatory Surgical ProceduresDatabases, FactualFemaleGastric BypassHumansLaparoscopyLength of StayLogistic ModelsLongitudinal StudiesMaleMiddle AgedMultivariate AnalysisObesity, MorbidOdds RatioPatient ReadmissionPostoperative ComplicationsTreatment OutcomeYoung AdultConceptsBody mass indexSerious complicationsGastric bypassMass indexMedian body mass indexLaparoscopic gastric bypass procedureHigher adverse eventsLaparoscopic Roux-EnY Gastric BypassGastric bypass proceduresLogistic regression analysisDistribution of LOSLogistic regression modelsLRYGB patientsLaparoscopic RouxRoux-enMedian LOSAdverse eventsMedian agePatient demographicsReadmission ratesBypass proceduresInsurance statusComplicationsClinical database
2013
Influence of Ethnicity on the Efficacy and Utilization of Bariatric Surgery in the USA
Sudan R, Winegar D, Thomas S, Morton J. Influence of Ethnicity on the Efficacy and Utilization of Bariatric Surgery in the USA. Journal Of Gastrointestinal Surgery 2013, 18: 130-136. PMID: 24101449, DOI: 10.1007/s11605-013-2368-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsBlack or African AmericanBody Mass IndexComorbidityDatabases, FactualDiabetes MellitusEthnicityFemaleFollow-Up StudiesGastric BypassGastroesophageal RefluxHealth Status DisparitiesHispanic or LatinoHumansHyperlipidemiasHypertensionLongitudinal StudiesMaleMiddle AgedObesitySleep Apnea, ObstructiveTreatment OutcomeUnited StatesWhite PeopleConceptsBaseline characteristicsThirty-day mortality rateBariatric Outcomes Longitudinal DatabaseGastric bypass surgerySerious adverse eventsPearson's chi-square testChi-square testPatterns of utilizationSmaller percent declineComorbidity burdenBariatric surgeryStudy patientsUnderwent surgeryAdverse eventsBypass surgeryMortality rateInfluence of ethnicityEthnic disparitiesHeavier BMIRYGBSurgeryCategorical variablesComorbiditiesBMIT-test
2012
The EMPOWER Study: Randomized, Prospective, Double-Blind, Multicenter Trial of Vagal Blockade to Induce Weight Loss in Morbid Obesity
Sarr MG, Billington CJ, Brancatisano R, Brancatisano A, Toouli J, Kow L, Nguyen NT, Blackstone R, Maher JW, Shikora S, Reeds DN, Eagon JC, Wolfe BM, O’Rourke R, Fujioka K, Takata M, Swain JM, Morton JM, Ikramuddin S, Schweitzer M, Chand B, Rosenthal R, The EMPOWER Study Group. The EMPOWER Study: Randomized, Prospective, Double-Blind, Multicenter Trial of Vagal Blockade to Induce Weight Loss in Morbid Obesity. Obesity Surgery 2012, 22: 1771-1782. PMID: 22956251, DOI: 10.1007/s11695-012-0751-8.Peer-Reviewed Original ResearchConceptsImportant weight lossControl groupWeight lossMorbid obesityVagal blockadePercent excess weight lossSubdiaphragmatic vagal nerveExcess weight lossSerious adverse eventsDuration of therapyDevice-related complicationsBody mass indexMain outcome measuresDevice useResultsStudy subjectsVagal transmissionAdverse eventsVagal nerveMulticenter trialMass indexFeasibility trialEMPOWER studyOutcome measuresInformed consentTherapyDeterminants of Adverse Events in Vascular Surgery
Hernandez-Boussard T, McDonald KM, Morton JM, Dalman RL, Bech FR. Determinants of Adverse Events in Vascular Surgery. Journal Of The American College Of Surgeons 2012, 214: 788-797. PMID: 22425449, PMCID: PMC4890555, DOI: 10.1016/j.jamcollsurg.2012.01.045.Peer-Reviewed Original ResearchConceptsPatient safety indicatorsAbdominal aortic aneurysm repairAortic aneurysm repairPotential adverse eventsAdverse eventsRisk-adjusted ratesVascular surgeryAneurysm repairVascular proceduresOpen abdominal aortic aneurysm repairEndovascular abdominal aortic aneurysm repairICD-9-CM codesLow-volume hospitalsPublic payersNationwide Inpatient SamplePatient safety eventsHospital stayNonwhite patientsPatient characteristicsPain patientsVascular patientsCarotid endarterectomyLower risk-adjusted rateOverall high rateProcedure indication
2011
Relationship between Patient Safety and Hospital Surgical Volume
Hernandez‐Boussard T, Downey JR, McDonald K, Morton JM. Relationship between Patient Safety and Hospital Surgical Volume. Health Services Research 2011, 47: 756-769. PMID: 22091561, PMCID: PMC3419887, DOI: 10.1111/j.1475-6773.2011.01310.x.Peer-Reviewed Original ResearchConceptsRisk-adjusted PSI ratesHospital volumePatient safety indicatorsAdverse eventsHospital-acquired adverse eventsCoronary artery bypass graftPSI ratesNationwide Inpatient Sample databaseHospital surgical volumeHospital adverse eventsArtery bypass graftHigh-volume hospitalsLow-volume hospitalsPreventable adverse eventsAbdominal aortic aneurysmCommon surgical procedureQuality health care deliveryHealth care deliveryRisk-adjusted ratesVolume tercilesGastric bypassVolume hospitalsBypass graftAortic aneurysmSurgical volumePL-110 Is ambulatory laparoscopic roux-en-y gastric bypass from the bariatric outcomes longitudinal database (BOLD) associated with higher adverse events?
Morton J, DeMaria E, Winegar D, Sherif B, Hutcher N, Blackstone R, Wolfe B. PL-110 Is ambulatory laparoscopic roux-en-y gastric bypass from the bariatric outcomes longitudinal database (BOLD) associated with higher adverse events? Surgery For Obesity And Related Diseases 2011, 7: 342-343. DOI: 10.1016/j.soard.2011.04.189.Peer-Reviewed Original Research
2006
Orogastric Tube Complications in Laparoscopic Roux-en-Y Gastric Bypass
Sanchez BS, Safadi BY, Kieran JA, Hsu GP, Brodsky JB, Curet MJ, Morton JM. Orogastric Tube Complications in Laparoscopic Roux-en-Y Gastric Bypass. Obesity Surgery 2006, 16: 443-447. PMID: 16608608, DOI: 10.1381/096089206776327350.Peer-Reviewed Original ResearchConceptsGastric pouch formationOrogastric tubeTube complicationsGastric bypassLaparoscopic RouxAdverse eventsPouch formationProlonged hospital stayTube-related complicationsY Gastric BypassAge 47 yearsLarge-bore orogastric tubeLaparoscopic RYGBPHospital stayRespiratory failureAnastomotic leakPatient demographicsAnastomotic revisionRetrospective reviewSignificant morbidityMortality 0Treatment optionsOpen procedureSurgical proceduresComplications