Identification of nitric oxide synthase as a protective locus against tuberculosis
MacMicking J, North R, LaCourse R, Mudgett J, Shah S, Nathan C. Identification of nitric oxide synthase as a protective locus against tuberculosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 5243-5248. PMID: 9144222, PMCID: PMC24663, DOI: 10.1073/pnas.94.10.5243.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAnimalsCarrier ProteinsCation Transport ProteinsCrosses, GeneticDisease SusceptibilityExonsFemaleGenotypeGlucocorticoidsHaplotypesHeterozygoteHomozygoteImmunity, InnateImmunosuppression TherapyIsoenzymesLungMaleMembrane ProteinsMiceMice, Inbred C57BLMice, Inbred StrainsMice, KnockoutMycobacterium tuberculosisNitric Oxide SynthasePolymerase Chain ReactionPolymorphism, GeneticTuberculosisConceptsNitric oxide synthaseOxide synthasePrimary Mycobacterium tuberculosis infectionInducible nitric oxide synthaseHigh-dose glucocorticoidsMycobacterium tuberculosis infectionWild-type miceWild-type littermatesHost immune systemChronic tuberculosisTuberculosis infectionImmune systemCritical host genesTuberculosisMycobacterium tuberculosisProtective genesMiceProtective locusNOS2Host genesSuch pathwaysResponse pathwaysSynthaseGlucocorticoidsLungInhibition of Viral Replication by Interferon-γ-Induced Nitric Oxide Synthase
Karupiah G, Xie Q, Buller R, Nathan C, Duarte C, MacMicking J. Inhibition of Viral Replication by Interferon-γ-Induced Nitric Oxide Synthase. Science 1993, 261: 1445-1448. PMID: 7690156, DOI: 10.1126/science.7690156.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid OxidoreductasesAnimalsArginineCell LineCells, CulturedEctromelia virusEctromelia, InfectiousEnzyme InductionFemaleHumansInterferon-gammaMacrophagesMiceMice, Inbred C57BLNitric OxideNitric Oxide SynthaseOmega-N-MethylarginineSimplexvirusTransfectionVaccinia virusVirus ReplicationConceptsViral replicationIFN-gammaHerpes simplex-1 virusNitric oxideDetectable NO synthesisSubstantial antiviral effectEctromelia virus infectionNitric oxide synthaseInducible NO synthaseIFN-gamma-treated macrophagesOxide synthaseAntiviral effectVirus infectionNO synthaseNO synthesisAntiviral activityInterferonEpithelial cellsMouse macrophagesCell productionMacrophagesCell typesSynthaseInhibitors