2019
Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study
Averill LA, Abdallah CG, Levey DF, Han S, Harpaz‐Rotem I, Kranzler HR, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH. Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study. Depression And Anxiety 2019, 36: 834-845. PMID: 31385647, DOI: 10.1002/da.22912.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderExecutive functionCognitive functioningStress disorderΕ4 carrier statusΕ4 carriersVeterans StudyCognitive dysfunctionAttention/concentrationGreater cognitive difficultiesLower cognitive functioningOlder U.S. veteransΕ4 allele carrier statusPerseverative errorsCognitive difficultiesReplication sampleCarrier statusCognitive functionImportance of assessingNational HealthCognitive declinePredictive effectApolipoprotein E gene polymorphismE gene polymorphismΕ4 allele carriers
2016
Late-life exacerbation of PTSD symptoms in US veterans: results from the National Health and Resilience in Veterans Study.
Mota N, Tsai J, Kirwin PD, Harpaz-Rotem I, Krystal JH, Southwick SM, Pietrzak RH. Late-life exacerbation of PTSD symptoms in US veterans: results from the National Health and Resilience in Veterans Study. The Journal Of Clinical Psychiatry 2016, 77: 348-54. PMID: 27046308, DOI: 10.4088/jcp.15m10101.Peer-Reviewed Original ResearchMeSH KeywordsAgedAgingExecutive FunctionFemaleHumansMaleMiddle AgedProspective StudiesRecurrenceStress Disorders, Post-TraumaticUnited StatesVeteransConceptsOlder US veteransPosttraumatic stress disorderUS veteransPTSD symptomsNational HealthVeterans StudyMultivariable logistic regression modelWorst traumaDelayed-onset posttraumatic stress disorderExecutive dysfunctionWave 2Population-based dataUS military veteransLogistic regression modelsWave 1Cohort studySignificant exacerbationGreater severitySymptomsOlder ageStress disorderSelf-reported cognitive difficultiesPotential targetMilitary veteransLater lifeNeuropsychological Functioning in Veterans with Posttraumatic Stress Disorder: Associations with Performance Validity, Comorbidities, and Functional Outcomes
Wrocklage KM, Schweinsburg BC, Krystal JH, Trejo M, Roy A, Weisser V, Moore TM, Southwick SM, Scott JC. Neuropsychological Functioning in Veterans with Posttraumatic Stress Disorder: Associations with Performance Validity, Comorbidities, and Functional Outcomes. Journal Of The International Neuropsychological Society 2016, 22: 399-411. PMID: 26892753, DOI: 10.1017/s1355617716000059.Peer-Reviewed Original ResearchConceptsNeuropsychological functioningGroup differencesValidity concernsPhysical health-related qualityDomains of speedPosttraumatic stress disorderInformation processing performanceEpisodic memoryAttention/Executive functionLanguage functioningPerformance validityCognitive functioningDisorder displayNeurocognitive domainsNeurocognitive findingsNeurocognitive functioningComparison participantsPTSD groupNeuropsychological testsStress disorderMost prior researchOccupational functioningNeuropsychological resultsPTSD status