2008
Relationship between ketamine-induced psychotic symptoms and NMDA receptor occupancy—a [123I]CNS-1261 SPET study
Stone JM, Erlandsson K, Arstad E, Squassante L, Teneggi V, Bressan RA, Krystal JH, Ell PJ, Pilowsky LS. Relationship between ketamine-induced psychotic symptoms and NMDA receptor occupancy—a [123I]CNS-1261 SPET study. Psychopharmacology 2008, 197: 401-408. PMID: 18176855, DOI: 10.1007/s00213-007-1047-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrief Psychiatric Rating ScaleDose-Response Relationship, DrugGuanidinesHumansInfusions, IntravenousIodine RadioisotopesKetamineMalePrefrontal CortexPsychoses, Substance-InducedReceptors, N-Methyl-D-AspartateSchizophreniaSingle-Blind MethodTomography, Emission-Computed, Single-PhotonConceptsBrief Psychiatric Rating ScaleVolume of distributionNMDA receptorsPsychotic symptomsN-methyl-D-aspartate receptorsKetamine-induced psychotic symptomsSingle photon emission tomographyNMDA receptor bindingEffects of ketamineNegative subscaleHealthy human controlsPsychiatric Rating ScaleNegative psychotic symptomsInferior frontal cortexKetamine administrationBolus infusionHealthy controls
1995
Yohimbine facilitated acoustic startle in combat veterans with post-traumatic stress disorder
Morgan CA, Grillon C, Southwick SM, Nagy LM, Davis M, Krystal JH, Charney DS. Yohimbine facilitated acoustic startle in combat veterans with post-traumatic stress disorder. Psychopharmacology 1995, 117: 466-471. PMID: 7604149, DOI: 10.1007/bf02246220.Peer-Reviewed Original ResearchConceptsAcoustic startle reflexRandomized double-blind placebo-controlled designCombat controlsDouble-blind placebo-controlled designAlpha-2 receptor antagonistEffects of yohimbinePlacebo-controlled designHealthy human controlsCombat veteransPost-traumatic stress disorderSevere stress resultsHealthy combat controlsInstantaneous rise timeSaline placeboCardiovascular effectsExcitatory effectsNeuronal reactivityNoradrenergic functionReceptor antagonistClinical studiesAcoustic startleYohimbinePTSD patientsPTSD subjectsNeurochemical basis