2013
Glutamatergic targets for new alcohol medications
Holmes A, Spanagel R, Krystal JH. Glutamatergic targets for new alcohol medications. Psychopharmacology 2013, 229: 539-554. PMID: 23995381, PMCID: PMC3811052, DOI: 10.1007/s00213-013-3226-2.Peer-Reviewed Original ResearchConceptsGlutamate systemGlycineB siteAlcohol-related behaviorsNMDA receptorsAlcohol abuseAlcohol consumptionN-methyl-D-aspartate receptorsChronic alcohol exposureElevated extracellular glutamatePathophysiology of alcoholismAMPA receptor subunitsAlcohol use disorderNovel pharmacotherapeutic approachesEffects of alcoholAlcohol medicationsBlocking NMDAHyperglutamatergic stateMetabotropic receptorsPharmacotherapeutic approachesAlcohol exposureExcess glutamateExtracellular glutamateGlutamate receptorsPreclinical studiesKainate receptors
2007
Imaging the Neurochemistry of Alcohol and Substance Abuse
Martinez D, Kim JH, Krystal J, Abi-Dargham A. Imaging the Neurochemistry of Alcohol and Substance Abuse. Neuroimaging Clinics Of North America 2007, 17: 539-555. PMID: 17983969, DOI: 10.1016/j.nic.2007.07.004.Peer-Reviewed Original Research
2005
Applications of Morphometric and Diffusion Tensor Magnetic Resonance Imaging to the Study of Brain Abnormalities in the Alcoholism Spectrum
Daurignac E, Toga A, Jones D, Aronen H, Hommer D, Jernigan T, Krystal J, Mathalon D. Applications of Morphometric and Diffusion Tensor Magnetic Resonance Imaging to the Study of Brain Abnormalities in the Alcoholism Spectrum. Alcohol Clinical And Experimental Research 2005, 29: 159-166. PMID: 15895490, DOI: 10.1097/01.alc.0000150891.72900.62.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingBrain abnormalitiesAlcohol exposureMicrostructural brain abnormalitiesMicrostructural brain alterationsBrain volume deficitsRecent magnetic resonance imagingPrenatal alcohol exposureWhite matter tract integrityWhite matter tractsStructural MRI methodsDiffusion tensor magnetic resonanceChronic alcoholicsBrain alterationsClinical subtypesMorphometric abnormalitiesAlcoholic drinkingVolume deficitsClinical subpopulationsResonance imagingTract integrityNeuropsychiatric diseasesUnique anatomyMicrostructural disruptionStudy of alcoholism